Metabolic syndrome in patients with psoriatic disease.
Metabolic syndrome in patients with psoriatic disease.
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DOI：
10.3899/jrheum.120237
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发表时间：
2012-07
影响因子：
--
通讯作者：
Yeung H
中科院分区：
文献类型：
--
作者：
Gelfand JM;Yeung H
银屑病是一种常见的Th-1和Th-17介导的慢性炎症性疾病，与代谢综合征有关，代谢综合征是一系列心血管危险因素，包括肥胖、高血压、血脂异常和胰岛素抵抗。重叠的炎症通路和遗传易感性可能是这种关联的潜在生物学联系。多项流行病学研究一致表明银屑病患者代谢综合征的患病率较高。最近建立了更严重的银屑病和更高的代谢综合征组分患病率之间的剂量反应关系。这种关联对银屑病的综合治疗具有重要的临床意义：银屑病患者应常规筛查代谢综合征并进行相应治疗以管理心脏代谢风险，而临床医生应监测对银屑病和代谢综合征共病患者治疗疗效和安全性的潜在影响。进一步的研究将是必要的，以建立这种关联的方向性，并探讨治疗对这些共病的影响。
Psoriasis is a common Th-1 and Th-17-mediated chronic inflammatory disease that has been associated with metabolic syndrome, a constellation of cardiovascular risk factors including obesity, hypertension, dyslipidemia, and insulin resistance, has been implicated. Overlapping inflammatory pathways and genetic susceptibility may be potential biologic links underlying this association. Multiple epidemiologic studies have consistently demonstrated higher prevalence of metabolic syndrome in patients with psoriasis. Dose-response relationships between more severe psoriasis and higher prevalence of metabolic syndrome components were recently established. This association has important clinical implications for the comprehensive management of psoriasis: Patients with psoriasis should be routinely screened for metabolic syndrome and treated accordingly to manage cardio-metabolic risk, while clinicians should monitor potential effects on treatment efficacy and safety in patients with co-morbid psoriasis and metabolic syndrome. Further research will be necessary to establish the directionality of this association and to explore the impact of treatment on these co-morbid diseases.
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影响因子：
120.7
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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DOI：
10.1111/j.1365-2133.2010.09941.x
发表时间：
2010-09
期刊：
The British journal of dermatology
影响因子：
--
作者：
Abuabara K;Azfar RS;Shin DB;Neimann AL;Troxel AB;Gelfand JM
通讯作者：
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影响因子：
11.1
作者：
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通讯作者：
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