Psychological stress induces temporary masticatory muscle mechanical sensitivity in rats.
Psychological stress induces temporary masticatory muscle mechanical sensitivity in rats.
复制标题
心理压力会引起大鼠暂时的咀嚼肌机械敏感性。
DOI：
10.1155/2011/720603
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发表时间：
2011
影响因子：
--
通讯作者：
Wu AZ
中科院分区：
文献类型：
--
作者：
Huang F;Zhang M;Chen YJ;Li Q;Wu AZ
为了探讨心理应激与咀嚼肌疼痛的关系，我们建立了交流应激动物模型，以确定心理应激是否会导致咀嚼肌机械敏感性升高，并研究应激解除后机械伤害知觉阈值的变化。48只雄性Sprague-Dawley大鼠分为对照组（CON）、足震组（FS，包括FS-1、FS-2和FS-3 3个亚组）、心理应激组（PS）和药物治疗组（DT）。将PS大鼠和DT大鼠置于交流箱内，每天1小时，观察相邻FS大鼠的心理反应。双侧颞肌和咬肌的机械伤害感受阈值的测量表明，心理应激与肌肉机械敏感性之间存在刺激-反应关系。注射地西泮的DT大鼠在面对心理压力时表现出与对照组几乎相同的咀嚼肌肉的机械敏感性。移除心理应激源14天后，机械伤害感受阈值恢复正常。这些发现表明心理压力与咀嚼肌疼痛有直接关系。消除应激源可能是缓解心理应激引起的机械敏感性增加的有效方法。
To explore the relationship between psychological stress and masticatory muscle pain, we created a communication stress animal model to determine whether psychological stress could induce increased mechanical sensitivity in masticatory muscles and to study the changes of mechanical nociceptive thresholds after stress removal. Forty-eight male Sprague-Dawley rats were divided into a control group (CON), a foot-shocked group (FS, including 3 subgroups recorded as FS-1, FS-2, and FS-3), a psychological stress group (PS), and a drug treatment group (DT). PS and DT rats were confined in a communication box for one hour a day to observe the psychological responses of neighboring FS rats.Measurements of the mechanical nociceptive thresholds of the bilateral temporal and masseter muscles showed a stimulus-response relationship between psychological stress and muscle mechanical sensitivity. The DT rats, who received a diazepam injection, showed almost the same mechanical sensitivity of the masticatory muscles to that of the control in response to psychological stress. Fourteen days after the psychological stressor was removed, the mechanical nociceptive thresholds returned to normal. These findings suggest that psychological stress is directly related to masticatory muscle pain. Removal of the stressor could be a useful method for relieving mechanical sensitivity increase induced by psychological stress.
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影响因子：
56.9
作者：
LEWIS, JW;CANNON, JT;LIEBESKIND, JC
通讯作者：
LIEBESKIND, JC
影响因子：
7.4
作者：
JORUM, E
通讯作者：
JORUM, E
影响因子：
3
作者：
PELLOW, S;CHOPIN, P;BRILEY, M
通讯作者：
BRILEY, M
影响因子：
7.4
作者：
Khasar, SG;Green, PG;Levine, JD
通讯作者：
Levine, JD
DOI：
10.1152/ajpgi.00500.2004
发表时间：
2005-07-01
影响因子：
4.5
作者：
Bradesi, S;Schwetz, I;Mayer, EA
通讯作者：
Mayer, EA