Multiplexing of motor information in the discharge of a collision detecting neuron during escape behaviors.

Multiplexing of motor information in the discharge of a collision detecting neuron during escape behaviors.
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逃生行为期间碰撞检测神经元放电时运动信息的多路复用。

DOI:
10.1016/j.neuron.2010.12.007
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发表时间:
2011-01-13
期刊:
影响因子:
16.2
通讯作者:
Gabbiani, Fabrizio
Gabbiani, Fabrizio
中科院分区:
医学1区
文献类型:
--
作者:
Fotowat, Haleh;Harrison, Reid R.;Gabbiani, Fabrizio

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蝗虫有一个已识别的神经元,即下行对侧运动检测器(DCMD),将即将发生的碰撞的视觉信息从大脑传递到胸部运动中心。我们建立了一个遥测系统,在行为自由的动物身上同时记录DCMD和参与跳跃执行的运动神经元的活动。对抗性腿部肌肉的联合收缩是一个必要的准备阶段,在DCMD的放电率超过阈值后被触发。此后,DCMD棘波的数量准确地预测了运动神经元的活动和跳跃的发生。此外,DCMD放电峰值的时间可以预测跳跃的时间。消融实验表明,DCMD与几乎相同的同侧下行神经元一起负责及时执行逃逸。因此,在单个神经元对即将发生的碰撞的感觉反应中,三个不同的特征--放电速率阈值、峰值放电时间和尖峰计数--可能控制着逃逸行为的三个不同的运动方面。
Locusts possess an identified neuron, the descending contralateral movement detector (DCMD), conveying visual information about impending collision from the brain to thoracic motor centers. We built a telemetry system to simultaneously record, in freely behaving animals, the activity of the DCMD and of motoneurons involved in jump execution. Co-contraction of antagonistic leg muscles, a required preparatory phase, was triggered after the DCMD firing rate crossed a threshold. Thereafter, the number of DCMD spikes predicted precisely motoneuron activity and jump occurrence. Additionally, the time of DCMD peak firing rate predicted that of jump. Ablation experiments suggest that the DCMD, together with a nearly identical ipsilateral descending neuron, is responsible for the timely execution of the escape. Thus, three distinct features that are multiplexed in a single neuron’s sensory response to impending collision – firing rate threshold, peak firing time, and spike count – likely control three distinct motor aspects of escape behaviors.
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