Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies.
Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies.
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习惯性饮食盐摄入量与胃癌风险之间的关联：观察性研究的系统回顾。
DOI：
10.1155/2012/808120
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发表时间：
2012
影响因子：
2
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Ge S;Feng X;Shen L;Wei Z;Zhu Q;Sun J
目的.病例对照和前瞻性研究的系统评价显示习惯性盐摄入与胃癌之间存在正相关。鉴于此后发表的新研究，我们进行了一项荟萃分析，以评估膳食盐摄入量与胃癌之间的关联。方法.检索了1992年1月至2012年1月在PubMed和Embase上发表的病例对照研究和队列研究。我们通过荟萃分析量化了盐摄入量与胃癌之间的关系。结果11项研究（7个病例对照和4个队列）最终被纳入荟萃分析（总人群：n = 2076498;事件：n = 12039）。高盐摄入与胃癌的合并优势比（OR = 2.05，95% CI [1.60，2.62]; P < 0.00001）显著正相关。在亚组荟萃分析中，当分析仅限于咸味食物摄入（OR = 2.41，95% CI [2.08，2.78]; P < 0.00001）以及亚洲（OR = 1.27，95% CI [1.22，1.32]; P < 0.00001）时，结果略有不同。没有证据表明样本量、暴露评估对效应估计有实质性影响。结论.系统性综述支持膳食盐摄入量与胃癌风险呈正相关的假设。
Purpose. Systematic reviews of case-control and prospective studies showed a positive association between habitual salt intake and gastric cancer. Given new studies published thereafter, we carried out a meta-analysis to assess the association between dietary salt intake and gastric cancer. Methods. Case-control studies and cohort studies published between January 1992 and January 2012 on PubMed and Embase were searched. We quantified associations between salt intake and gastric cancer with meta-analysis. Results. Eleven studies (7 case controls and 4 cohorts) finally were included in the meta-analysis (total population: n = 2076498; events: n = 12039). The combined odds ratio showed significantly positive association between high salt intake and gastric cancer compared with low salt intake (OR = 2.05, 95% CI [1.60, 2.62]; P < 0.00001). In subgroup meta-analysis, findings were slightly different when analyses were restricted to salty food intake (OR = 2.41, 95% CI [2.08, 2.78]; P < 0.00001) as well as in Asia (OR = 1.27 95% CI [1.22, 1.32]; P < 0.00001). There was no evidence that sample size, exposure assessment substantially influenced the estimate of effects. Conclusions. The systemic review supports the hypothesis that dietary salt intake is positively associated with the risk of gastric cancer.
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影响因子：
4.3
作者：
Campos, Francia;Carrasquilla, Gabriel;Akiba, Suminori
通讯作者：
Akiba, Suminori
影响因子：
11.2
作者：
Loh, John T.;Torres, Victor J.;Cover, Timothy L.
通讯作者：
Cover, Timothy L.
影响因子：
3.2
作者：
Gancz, Hanan;Jones, Kathleen R.;Merrell, D. Scott
通讯作者：
Merrell, D. Scott
影响因子：
4.1
作者：
Chen, W;Weisburger, JH;Hecht, SS
通讯作者：
Hecht, SS
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N