High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry.
High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry.
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DOI：
10.1002/sia.4910
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发表时间：
2013-01
影响因子：
1.7
通讯作者：
Alexander, Morgan
中科院分区：
文献类型：
--
作者：
Hook, Andrew L.;Scurr, David J.;Anderson, Daniel G.;Langer, Robert;Williams, Paul;Davies, Martyn;Alexander, Morgan
响应于外部刺激而改变其化学或物理性质的可切换材料允许对材料-生物相互作用的时间控制，因此，对于许多生物材料应用是感兴趣的。我们的兴趣是发现适合某些生物系统特定要求的新材料。已经开发了一种高通量方法来筛选聚合物库的热响应性，这导致了新的可切换材料的鉴定。为了阐明材料切换的机制，飞行时间二次离子质谱法已被用来分析在不同温度下的聚合物样品的顶部2纳米。某些分子片段的表面富集已被确定在不同温度下的飞行时间二次离子质谱分析，表明改变分子构象。在一个示例中，推断出伸展和折叠构象之间的切换。版权所有© 2012约翰威利父子有限公司.
Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discovery of new materials suitable to the specific requirements of certain biological systems. A high throughput methodology has been developed to screen a library of polymers for thermo-responsiveness, which has resulted in the identification of novel switchable materials. To elucidate the mechanism by which the materials switch, time-of-flight secondary ion mass spectrometry has been employed to analyse the top 2 nm of the polymer samples at different temperatures. The surface enrichment of certain molecular fragments has been identified by time-of-flight secondary ion mass spectrometry analysis at different temperatures, suggesting an altered molecular conformation. In one example, a switch between an extended and collapsed conformation is inferred. Copyright © 2012 John Wiley & Sons, Ltd.
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影响因子：
29.4
作者：
Urquhart, Andrew J.;Anderson, Daniel G.;Davies, Martyn C.
通讯作者：
Davies, Martyn C.
影响因子：
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Cole, Martin A.;Jasieniak, Marek;Griesser, Hans J.
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Griesser, Hans J.
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Fechler, Nina;Badi, Nezha;Lutz, Jean-Francois
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Lutz, Jean-Francois
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Voelcker, Nicolas H.
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作者：
Wischerhoff, Erik;Uhlig, Katja;Lutz, Jean-Francois
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Lutz, Jean-Francois