Influence of SLC6A3 and COMT variation on neural activation during response inhibition.
Influence of SLC6A3 and COMT variation on neural activation during response inhibition.
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DOI：
10.1016/j.biopsycho.2009.03.005
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发表时间：
2009-07
影响因子：
2.6
通讯作者：
Canli, Turhan
中科院分区：
文献类型：
--
作者：
Congdon, Eliza;Constable, R. Todd;Lesch, Klaus Peter;Canli, Turhan
有证据表明抑制控制与神经和遗传相关，但联合收割机结合这些信息的尝试有限。本研究验证了两种多巴胺能多态性，SLC 6A 3和COMT，在反应抑制过程中影响神经激活的假设。健康成年人对这些多态性进行基因分型，并在进行功能性磁共振成像（fMRI）时进行反应抑制测量。结果支持的作用，关键额纹状体区域的反应抑制。此外，结果支持SLC 6A 3和COMT变体对抑制期间的神经活动的显著影响，与SLC 6A 3 10/10基因型或COMT瓦尔/瓦尔基因型的携带者相比，SLC 6A 3 9-等位基因或COMT Met-等位基因的携带者在抑制期间具有更大的激活。这些结果补充了越来越多的文献，表明抑制控制对多巴胺功能的变化很敏感，并表明这种变化可能在个体基因型水平上是可检测的。
There is evidence concerning the neural and genetic correlates of inhibitory control, but there have been limited attempts to combine this information. This study tested the hypothesis that two dopaminergic polymorphisms, SLC6A3 and COMT, influence neural activation during response inhibition. Healthy adults were genotyped for these polymorphisms and performed a measure of response inhibition while undergoing functional magnetic resonance imaging (fMRI). Results support the role of key frontostriatal regions underlying response inhibition. Furthermore, results support a significant influence of SLC6A3 and COMT variants on neural activity during inhibition, with greater activation during inhibition in carriers of the SLC6A3 9-allele or the COMT met-allele as compared to carriers of the SLC6A3 10/10 genotype or the COMT val/val genotype. These results add to a growing literature suggesting that inhibitory control is sensitive to variation in dopamine function, and suggest that this variation may be detectable at the level of individuals’ genotypes.
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DOI：
10.1523/jneurosci.4858-08.2009
发表时间：
2009-01-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bertolino A;Fazio L;Di Giorgio A;Blasi G;Romano R;Taurisano P;Caforio G;Sinibaldi L;Ursini G;Popolizio T;Tirotta E;Papp A;Dallapiccola B;Borrelli E;Sadee W
通讯作者：
Sadee W
DOI：
10.1002/ajmg.b.30572
发表时间：
2007-12-05
影响因子：
2.8
作者：
Brookes, Keeley J.;Neale, Benjamin M.;D'Souza, Ursula M.
通讯作者：
D'Souza, Ursula M.
影响因子：
3.2
作者：
Chambers, CD;Bellgrove, MA;Mattingley, JB
通讯作者：
Mattingley, JB
影响因子：
4.2
作者：
Brown, Sarah M.;Manuck, Stephen B.;Hariri, Ahmad R.
通讯作者：
Hariri, Ahmad R.
影响因子：
10.6
作者：
Bruder, GE;Keilp, JG;Gilliam, TC
通讯作者：
Gilliam, TC