Neuroanatomical substrates of foresight in schizophrenia.
Neuroanatomical substrates of foresight in schizophrenia.
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DOI：
10.1016/j.schres.2008.05.012
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发表时间：
2008-08
影响因子：
4.5
通讯作者：
Keshavan, Matcheri S.
中科院分区：
文献类型：
--
作者：
Eack, Shaun M.;George, Manish M.;Prasad, Konasale M. R.;Keshavan, Matcheri S.
思考一个人行为的长期后果并使用这些信息来指导现在和未来行动的能力，通常被称为远见，是一种关键的高阶认知能力，可能在精神分裂症患者中缺乏，并大大限制了这些人从疾病中恢复的程度。本研究调查了精神分裂症患者预见性的神经解剖学基础，以确定可能导致这一人群预见性受损的潜在脑区。参与者在早期过程中的精神分裂症或情感障碍（N = 50）进行了评估，使用结构磁共振成像和临床医生评定的前瞻性和精神病理学的措施。基于体素的形态测量学被用来研究前瞻性和腹内侧前额叶，眶额和扣带回皮质的区域灰质体积之间的关系。在校正多重比较后，在右眶额、腹内侧前额叶和后扣带回皮质以及左腹内侧前额叶和前扣带回皮质中观察到远见和灰质体积密度之间存在显著正相关。这些关系在调整年龄、性别、病程和精神病理学后仍然存在。更好的预见能力与右侧眶额/腹内侧前额叶皮质的灰质增加密切相关，这表明该区域的灰质体积减少可能与精神分裂症的预见能力受损有关。对未来研究的意义和方向进行了讨论。
The ability to think of the long-term consequences of one's behavior and use this information to guide present and future actions, commonly referred to as foresight, is a key higher-order cognitive ability that may be deficient among persons with schizophrenia and substantially limit the degree to which such individuals experience a functional recovery from the disease. This research investigated the neuroanatomical basis of foresight in schizophrenia, in order to identify potential brain regions that may underly impaired foresightfulness among this population. Participants in the early course of schizophrenia or schizoaffective disorder (N = 50) were assessed using structural magnetic resonance imaging and clinician-rated measures of foresight and psychopathology. Voxel-based morphometry was used to examine the relationship between foresight and regional gray matter volume in the ventromedial prefrontal, orbitofrontal and cingulate cortices. Significant positive associations were observed between foresight and gray matter volume density in the right orbitofrontal, ventromedial prefrontal, and posterior cingulate cortices, as well as the left ventromedial prefrontal and anterior cingulate cortices, after correcting for multiple comparisons. These relationships persisted after adjusting for age, gender, illness duration, and psychopathology. Better foresight was most strongly associated with increased gray matter in the right orbitofrontal/ventromedial prefrontal cortex, suggesting that reductions in gray matter volume in this region may be associated with impaired foresight in schizophrenia. Implications and directions for future research are discussed.
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