ZFAS1: A novel vital oncogenic lncRNA in multiple human cancers.
ZFAS1: A novel vital oncogenic lncRNA in multiple human cancers.
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ZFAS1：多种人类癌症中的一种新型重要致癌 lncRNA
DOI：
10.1111/cpr.12513
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发表时间：
2019-01
影响因子：
8.5
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
He A;He S;Li X;Zhou L
长链非编码RNA（lncRNA）是一类长度超过200个核苷酸的非编码内源性单链RNA，由RNA聚合酶II转录。越来越多的证据表明，lncRNA通过在转录、转录后、表观遗传和翻译水平上修饰基因表达，在多种生理和病理过程中发挥关键作用。许多研究表明，lncRNA作为潜在的癌基因或肿瘤抑制因子，在肿瘤的发生和发展中起着重要的调控作用。ZNFX 1反义RNA 1（ZFAS 1）是一种以含锌指NFX 1-型1（ZNFX 1）的反义方向转录的新型lncRNA，发现在多种癌症（如胃癌和肝细胞癌）中增加，有助于癌症的发生和进展。本文就ZFAS 1在多种肿瘤发生发展中的作用及其分子机制的研究进展作一综述。
Long noncoding RNAs (lncRNAs) are a class of noncoding, endogenous, single‐stranded RNAs longer than 200 nucleotides in length that are transcribed by RNA polymerase II. Mounting evidence has indicated that lncRNAs play key roles in several physiological and pathological processes by modifying gene expression at the transcriptional, posttranscriptional, epigenetic, and translation levels. Many reports have demonstrated that lncRNAs function as potential oncogene or tumour suppressors and thus play vital regulatory roles in tumourigenesis and tumour progression. ZNFX1 antisense RNA 1 (ZFAS1), a novel lncRNA transcribed in the antisense orientation of zinc finger NFX1‐type containing 1(ZNFX1), was found to be increased in multiple cancers, such as gastric cancer and hepatocellular carcinoma, contributing to cancer development and progression. In the present review, we summarized recent progression on study of the functions and underlying molecular mechanisms of ZFAS1 related to occurrence and development of multiple cancers.
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影响因子：
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作者：
Lan T;Lan X;Li G;Zheng Z;Zhang M;Qin F
通讯作者：
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影响因子：
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通讯作者：
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