Self-Reported Weather Sensitivity is Associated with Clinical Symptoms and Structural Abnormalities in Patients with Knee Osteoarthritis: A Cross-Sectional Study.
Self-Reported Weather Sensitivity is Associated with Clinical Symptoms and Structural Abnormalities in Patients with Knee Osteoarthritis: A Cross-Sectional Study.
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自我报告的天气敏感性与膝关节骨关节炎患者的临床症状和结构异常相关：一项横断面研究。
DOI：
10.1007/s40744-021-00340-w
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发表时间：
2021-09
影响因子：
3.8
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Xue Y;Chen Y;Jiang D;Wang L;Wang X;Li M;Wu Y;Zhang M;Pang J;Zhan H;Zheng Y;Ding D;Cao Y
膝关节骨关节炎(KOA)患者经常抱怨临床症状受天气相关因素的影响。本研究的目的是使用横断面分析来确定天气敏感性是否与膝关节骨性关节炎患者的临床症状和结构异常有关。来自80名参与者的数据来自冯汉时对骨质疏松症的影响研究，这是一项由中国于2015年发起的骨质疏松症队列研究。每个参与者的天气敏感度都是由一份自我报告的问卷确定的。以下测量用于评估临床结果：西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)用于症状，半定量全身磁共振成像评分(WORMS)用于软骨缺陷和磁共振成像(MRI)的骨髓异常。采用卡方检验、Cochran-Armitage趋势分析和回归分析评价天气敏感性与膝关节骨性关节炎患者的WOMAC和蠕虫的关系。大多数KOA参与者(57.5%)认为天气会影响他们的膝关节临床症状。在调整了年龄、性别和体重指数后，天气敏感性不仅与膝关节疼痛[OR = 3.3(95%CI 1.1，9.9)，P = 0.032]、功能障碍[OR = 5.5(95%CI 1.8，16.8)，P = 0.003]和总体临床症状[OR = 3.3(95%CI 1.1，10.2)，P = 0.034]有关，并伴有软骨缺损[OR = 3.1(95%CI 1.1，8.5)，P = 0.027]和骨髓异常[OR = 3.0(95%CI 1.1，8.1)，P = 0.029]。在膝关节骨性关节炎患者中，天气敏感性与临床症状和结构异常有关。对于因果关系，未来的纵向研究是必要的。网上版载有补充材料，可在10.1007/s40744-021-00340-w查阅。
Patients with knee osteoarthritis (KOA) often complain about clinical symptoms affected by weather-related factors. The purpose of the present study was to use cross-sectional analysis to determine whether weather sensitivity was associated with clinical symptoms, as well as structure abnormalities, in KOA patients. Data from 80 participants were obtained from the Feng Hans Shi Effects on OA (FHS) study, an OA cohort study initiated in China in 2015. The weather sensitivity of each participant was determined by a self-reported questionnaire. The following measurements were used to assess clinical outcomes: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for symptoms, and semi-quantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS) for cartilage defects and marrow abnormalities of magnetic resonance imaging (MRI). Chi-square with Cochran–Armitage test for trend and regression analysis were used to evaluate the associations between weather sensitivity and WOMAC and WORMS of KOA patients. Most of the KOA participants (57.5%) perceived the weather as affecting their knee-joint clinical symptoms. After adjusting for age, gender, and body mass index (BMI), weather sensitivity was not only associated with knee pain [OR = 3.3 (95% CI 1.1, 9.9), P = 0.032], dysfunction [OR = 5.5 (95% CI 1.8, 16.8), P = 0.003], and overall clinical symptoms [OR = 3.3 (95% CI 1.1, 10.2), P = 0.034], but also associated with cartilage defect [OR = 3.1 (95% CI 1.1, 8.5), P = 0.027] and marrow abnormality [OR = 3.0 (95% CI 1.1, 8.1), P = 0.029]. In KOA patients, weather sensitivity was associated with clinical symptoms and structural abnormalities. Future longitudinal study is warranted for the causal relationship. The online version contains supplementary material available at 10.1007/s40744-021-00340-w.
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影响因子：
0.6
作者：
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通讯作者：
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