Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica.
Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica.
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大肠杆菌O157：H7，沙门氏菌和耶尔森氏菌小肠结肠炎的肾上腺素能和多巴胺能受体拮抗剂对儿茶酚胺诱导的肾上腺素能受体拮抗剂的封锁。
DOI：
10.1186/1471-2180-7-8
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发表时间：
2007-01-30
期刊：
影响因子：
4.2
通讯作者：
Lyte, Mark
中科院分区：
文献类型：
--
作者：
Freestone, Primrose P. E.;Haigh, Richard D.;Lyte, Mark
十多年前，人们首次证实了儿茶酚胺刺激细菌生长的能力。然而，关于假定的细菌肾上腺素能和/或多巴胺能受体的性质，甚至这种受体的结合特性在不同物种之间是否相似，仍然知之甚少，其中儿茶酚胺（去甲肾上腺素、肾上腺素和多巴胺）可以结合并发挥其作用。使用特定的儿茶酚胺受体拮抗剂表明，只有α肾上腺素能拮抗剂而不是β肾上腺素能拮抗剂能够阻断去甲肾上腺素和肾上腺素诱导的生长，而使用多巴胺能拮抗剂可以实现对多巴胺介导的生长的拮抗。肾上腺素能和多巴胺能拮抗剂的作用机制是高度特异性的，不涉及阻断儿茶酚胺促进铁的获得。使用放射性标记的去甲肾上腺素表明，肾上腺素能拮抗剂可能通过抑制儿茶酚胺摄取发挥作用。目前的数据表明，特定病原体对特定激素产生反应的能力取决于病原体引起疾病的宿主解剖区域以及特定激素的产生受到限制的神经解剖特异性;并且两者在解剖学上彼此巧合。因此，本报告表明，对胃肠道具有高度排他性的病原体已经进化出对神经内分泌激素（如去甲肾上腺素和多巴胺）的反应系统，但不包括肠神经系统中发现的肾上腺素。
The ability of catecholamines to stimulate bacterial growth was first demonstrated just over a decade ago. Little is still known however, concerning the nature of the putative bacterial adrenergic and/or dopaminergic receptor(s) to which catecholamines (norepinephrine, epinephrine and dopamine) may bind and exert their effects, or even whether the binding properties of such a receptor are similar between different species. Use of specific catecholamine receptor antagonists revealed that only α, and not β, adrenergic antagonists were capable of blocking norepinephrine and epinephrine-induced growth, while antagonism of dopamine-mediated growth was achieved with the use of a dopaminergic antagonist. Both adrenergic and dopaminergic antagonists were highly specific in their mechanism of action, which did not involve blockade of catecholamine-facilitated iron-acquisition. Use of radiolabeled norepinephrine suggested that the adrenergic antagonists could be acting by inhibiting catecholamine uptake. The present data demonstrates that the ability of a specific pathogen to respond to a particular hormone is dependent upon the host anatomical region in which the pathogen causes disease as well as the neuroanatomical specificity to which production of the particular hormone is restricted; and that both are anatomically coincidental to each other. As such, the present report suggests that pathogens with a high degree of exclusivity to the gastrointestinal tract have evolved response systems to neuroendocrine hormones such as norepinephrine and dopamine, but not epinephrine, which are found with the enteric nervous system.
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影响因子：
3.2
作者：
Anderson, Mark T.;Armstrong, Sandra K.
通讯作者：
Armstrong, Sandra K.
影响因子：
3.1
作者：
Burton, CL;Chhabra, SR;Williams, P
通讯作者：
Williams, P
影响因子：
2.1
作者：
Freestone, PPE;Haigh, RD;Lyte, M
通讯作者：
Lyte, M
影响因子：
3.2
作者：
Freestone, PPE;Lyte, M;Williams, PH
通讯作者：
Williams, PH
影响因子：
5.3
作者：
Hills, T;Brockie, PJ;Maricq, AV
通讯作者：
Maricq, AV