Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System.
Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System.
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DOI：
10.3390/cells9091990
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发表时间：
2020-08-29
期刊：
影响因子：
6
通讯作者：
Madduri S
中科院分区：
文献类型：
--
作者：
Hopf A;Schaefer DJ;Kalbermatten DF;Guzman R;Madduri S
神经断伤（神经纤维的完全切断）后的功能恢复通常很差，需要外科手术。特别是对于较长的间隙（>3 mm），近端到远端部分的端对端缝合是不可能的，因此需要神经移植物植入。人工神经移植物，即，中空纤维、水凝胶、脱乙酰壳多糖、胶原导管和脱细胞支架具有希望，只要这些结构中填充有被广泛接受以促进外周和脊髓再生的许旺细胞（SC）。然而，这些细胞必须从健康的外周神经收集，导致治疗的显著时间延迟和供体的不期望的发病率。因此，显然需要探索具有类似于SC的再生潜力的细胞的可行来源。为此，我们分析了从不同来源的干细胞（即，间充质干细胞、多能干细胞和遗传编程的体细胞），并比较它们促进轴突再生的生物学性能。因此，目前的审查占目前的发展领域的小细胞肺癌分化，其在外周和中枢神经系统损伤的应用，并提供了见解，为未来的战略。
Functional recovery after neurotmesis, a complete transection of the nerve fiber, is often poor and requires a surgical procedure. Especially for longer gaps (>3 mm), end-to-end suturing of the proximal to the distal part is not possible, thus requiring nerve graft implantation. Artificial nerve grafts, i.e., hollow fibers, hydrogels, chitosan, collagen conduits, and decellularized scaffolds hold promise provided that these structures are populated with Schwann cells (SC) that are widely accepted to promote peripheral and spinal cord regeneration. However, these cells must be collected from the healthy peripheral nerves, resulting in significant time delay for treatment and undesired morbidities for the donors. Therefore, there is a clear need to explore the viable source of cells with a regenerative potential similar to SC. For this, we analyzed the literature for the generation of Schwann cell-like cells (SCLC) from stem cells of different origins (i.e., mesenchymal stem cells, pluripotent stem cells, and genetically programmed somatic cells) and compared their biological performance to promote axonal regeneration. Thus, the present review accounts for current developments in the field of SCLC differentiation, their applications in peripheral and central nervous system injury, and provides insights for future strategies.
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