The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes.
The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes.
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DOI：
10.3389/fphys.2018.00419
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发表时间：
2018
影响因子：
4
通讯作者：
Berthiaume F
中科院分区：
文献类型：
--
作者：
Krzyszczyk P;Schloss R;Palmer A;Berthiaume F
巨噬细胞在成人伤口愈合的所有阶段都起着关键作用，这些阶段是炎症、增殖和重塑。随着伤口愈合，局部巨噬细胞群体从主要促炎（M1样表型）转变为抗炎（M2样表型）。不愈合的慢性伤口，如压力，动脉，静脉和糖尿病溃疡无限期地保持在炎症-伤口愈合的第一阶段。因此，局部巨噬细胞保留促炎特征。这篇综述讨论了单核细胞和巨噬细胞在急性伤口愈合中的生理学以及文献中描述的体外和体内模型的不同表型。我们还讨论了在慢性伤口中巨噬细胞群体中发生的畸变，并试图通过治疗方法恢复巨噬细胞功能。这些包括内源性M1衰减、外源性M2补充和通过间充质干细胞、生长因子、生物材料、血红素加氧酶-1（HO-1）表达和氧治疗的内源性巨噬细胞调节/M2促进。我们认识到这一领域存在的挑战和争议，如巨噬细胞表型命名的标准化，其独特作用的定义和理解哪种表型是最佳的，以促进慢性伤口愈合。
Macrophages play key roles in all phases of adult wound healing, which are inflammation, proliferation, and remodeling. As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes). Non-healing chronic wounds, such as pressure, arterial, venous, and diabetic ulcers indefinitely remain in inflammation—the first stage of wound healing. Thus, local macrophages retain pro-inflammatory characteristics. This review discusses the physiology of monocytes and macrophages in acute wound healing and the different phenotypes described in the literature for both in vitro and in vivo models. We also discuss aberrations that occur in macrophage populations in chronic wounds, and attempts to restore macrophage function by therapeutic approaches. These include endogenous M1 attenuation, exogenous M2 supplementation and endogenous macrophage modulation/M2 promotion via mesenchymal stem cells, growth factors, biomaterials, heme oxygenase-1 (HO-1) expression, and oxygen therapy. We recognize the challenges and controversies that exist in this field, such as standardization of macrophage phenotype nomenclature, definition of their distinct roles and understanding which phenotype is optimal in order to promote healing in chronic wounds.
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影响因子：
5.7
作者：
Dai T;Tanaka M;Huang YY;Hamblin MR
通讯作者：
Hamblin MR
影响因子：
2.9
作者：
da Costa, RM;Jesus, FMR;Mendes, M
通讯作者：
Mendes, M
DOI：
10.1111/wrr.12205
发表时间：
2014-09
期刊：
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
影响因子：
--
作者：
Barrientos S;Brem H;Stojadinovic O;Tomic-Canic M
通讯作者：
Tomic-Canic M
影响因子：
4.6
作者：
Benson, RM;Minter, LM;Granowitz, EV
通讯作者：
Granowitz, EV
影响因子：
0.7
作者：
Cans, Ginger S.;Gibson, Teresa B.;Christina, James R.
通讯作者：
Christina, James R.