Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects.
Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects.
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DOI：
10.1586/eri.11.59
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发表时间：
2011-07
影响因子：
5.7
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Dai T;Tanaka M;Huang YY;Hamblin MR
自大约200年前被发现以来，壳聚糖作为一种阳离子天然聚合物，因其止血、促进愈合、抗菌、无毒、生物相容性和生物可降解等特性，在伤口处理中被广泛用作局部敷料。本文涵盖了壳聚糖及其衍生物和复合物的抗菌和伤口愈合作用，以及它作为一种载体将生物药剂、抗菌剂和生长因子输送到组织中的应用。有关壳聚糖在伤口和烧伤中应用的研究可分为体外研究、动物研究和临床研究。壳聚糖制剂分为天然壳聚糖、壳聚糖配方、与其他物质形成的复合物和衍生物。壳聚糖可用于预防或治疗伤口和烧伤感染，这不仅是因为其内在的抗菌特性，还因为它能够将外源性抗菌剂输送到伤口和烧伤处。它还可用作生长因子的缓释药物输送载体以促进伤口愈合。该领域大量的研究文献表明，壳聚糖将继续在伤口和烧伤处理中发挥重要作用。
Since its discovery approximately 200 years ago, chitosan, as a cationic natural polymer, has been widely used as a topical dressing in wound management owing to its hemostatic, stimulation of healing, antimicrobial, nontoxic, biocompatible and biodegradable properties. This article covers the antimicrobial and wound-healing effects of chitosan, as well as its derivatives and complexes, and its use as a vehicle to deliver biopharmaceuticals, antimicrobials and growth factors into tissue. Studies covering applications of chitosan in wounds and burns can be classified into in vitro, animal and clinical studies. Chitosan preparations are classified into native chitosan, chitosan formulations, complexes and derivatives with other substances. Chitosan can be used to prevent or treat wound and burn infections not only because of its intrinsic antimicrobial properties, but also by virtue of its ability to deliver extrinsic antimicrobial agents to wounds and burns. It can also be used as a slow-release drug-delivery vehicle for growth factors to improve wound healing. The large number of publications in this area suggests that chitosan will continue to be an important agent in the management of wounds and burns.
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影响因子：
4.9
作者：
Dai, Tianhong;Tegos, George P.;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
2.7
作者：
Alemdaroglu, C;Degim, Z;Erdogan, D
通讯作者：
Erdogan, D
影响因子：
6.6
作者：
BARTONE, FF;ADICKES, ED
通讯作者：
ADICKES, ED
影响因子：
14
作者：
Boucard, Nadge;Viton, Christophe;Domard, Alain
通讯作者：
Domard, Alain
影响因子：
6.1
作者：
Belalia, Rachid;Grelier, Stephane;Coma, Veronique
通讯作者：
Coma, Veronique