Recombinational histories of avian infectious bronchitis virus and turkey coronavirus.

Recombinational histories of avian infectious bronchitis virus and turkey coronavirus.
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DOI:
10.1007/s00705-011-1061-5
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发表时间:
2011-10
影响因子:
2.7
通讯作者:
Hughes AL
Hughes AL
中科院分区:
医学4区
文献类型:
--
作者:
Hughes AL

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禽传染性支气管炎(AIBV)和火鸡冠状病毒(TCoV)全基因组的系统发育分析支持了这两种病毒之间发生了大量重组事件的假设。尽管两组病毒在刺突蛋白序列上有明显差异,但编码该蛋白的基因(S)没有显示出正选择或突变率升高的证据。相反,数据表明,重组事件使两组病毒之间除S基因外的基因组部分均质化,同时继续保持S基因的两个不同的、古老的分化版本。后一种假设得到了代表性冠状病毒S蛋白系统发育的支持,其中AIBV和TCoV的S蛋白属于同一进化支。本文的在线版本(doi:10.1007/s00705-011-1061-5)包含补充材料,授权用户可使用。
Phylogenetic analysis of complete genomes of the avian coronaviruses avian infectious bronchitis (AIBV) and turkey coronavirus (TCoV) supported the hypothesis that numerous recombination events have occurred between these viruses. Although the two groups of viruses differed markedly in the sequence of the spike protein, the gene (S) encoding this protein showed no evidence of positive selection or of an elevated mutation rate. Rather, the data suggested that recombination events have homogenized the portions of the genome other than the S gene between the two groups of viruses, while continuing to maintain the two distinct, anciently diverged versions of the S gene. The latter hypothesis was supported by a phylogeny of S proteins from representative coronaviruses, in which S proteins of AIBV and TCoV fell in the same clade. The online version of this article (doi:10.1007/s00705-011-1061-5) contains supplementary material, which is available to authorized users.
DOI: 10.3201/eid1507.090067
发表时间: 2009-07
影响因子: 11.8
作者:
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