Spindle-related brain activation in patients with insomnia disorder: An EEG-fMRI study
Spindle-related brain activation in patients with insomnia disorder: An EEG-fMRI study
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失眠症患者纺锤体相关的大脑激活：脑电图-功能磁共振成像研究
DOI：
10.1007/s11682-021-00544-2
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发表时间：
2021-05
影响因子：
3.2
通讯作者：
Sun Hongqiang
中科院分区：
文献类型：
--
作者：
Shao Yan;Zou Guangyuan;Tabarak Serik;Chen Jie;Gao Xuejiao;Yao Ping;Liu Jiayi;Li Yuezhen;Xiong Nana;Pan Wen;Ma Mengying;Zhou Shuqin;Xu Jing;Ma Yundong;Deng Jiahui;Sun Qiqing;Bao Yanping;Sun Wei;Shi Jie;Zou Qihong;Gao Jia-Hong;Sun Hongqiang
睡眠纺锤波与睡眠保护、抑郁和焦虑有关。然而，支持失眠症（ID）睡眠保护和情绪调节不足的纺锤体相关脑成像机制仍不清楚。本研究的目的是探讨纺锤波相关脑激活与ID患者的睡眠质量、抑郁和焦虑症状之间的关系。通过广告招募了46名参与者（n= 28名女性，18-60岁），其中16名为ID患者，根据精神疾病诊断和统计手册第五版，30名为对照组。在睡眠过程中，使用同步脑电图和功能性磁共振成像获得的多模态数据分析了纺锤体相关脑激活的组间差异。与对照组相比，ID患者的双侧扣带回中与纺锤体相关的脑激活显著减少（家族误差校正值为0.05，簇大小为4401 mm ~ 3）。合并样本中扣带回激活与匹兹堡睡眠质量指数评分（r=-0.404，p = 0.005）和焦虑自评量表评分（r=-0.364，p = 0.013）呈负相关。这些发现强调了扣带回中纺锤体相关的脑激活在ID的主观睡眠质量和情绪调节中的关键作用。
Sleep spindles have been implicated in sleep protection, depression and anxiety. However, spindle-related brain imaging mechanism underpinning the deficient sleep protection and emotional regulation in insomnia disorder (ID) remains elusive. The aim of the current study is to investigate the relationship between spindle-related brain activations and sleep quality, symptoms of depression and anxiety in patients with ID. Participants (n= 46,28females, 18–60 years) were recruited through advertisements including 16 with ID, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and 30 matched controls. Group differences in spindle-related brain activations were analyzed using multimodality data acquired with simultaneous electroencephalography and functional magnetic resonance imaging during sleep. Compared with controls, patients with ID showed significantly decreased bilateral spindle-related brain activations in the cingulate gyrus (familywise error correctedp˂ 0.05, cluster size4401mm3). Activations in the cingulate gyrus were negatively correlated withPittsburgh Sleep Quality Index scores (r= -0.404,p= 0.005)andSelf-Rating Anxiety Scale scores (r= -0.364,p= 0.013), in the pooled sample. These findings underscore the key role of spindle-related brain activations in the cingulate gyrus in subjective sleep quality and emotional regulation in ID.
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影响因子：
2.9
作者：
Dang-Vu TT;Salimi A;Boucetta S;Wenzel K;O'Byrne J;Brandewinder M;Berthomier C;Gouin JP
通讯作者：
Gouin JP
影响因子：
6.6
作者：
J. Meers;R. Ferri;O. Bruni;C. Alfano
通讯作者：
J. Meers;R. Ferri;O. Bruni;C. Alfano
原发性失眠患者的区域同质性变化
影响因子：
5.9
作者：
Wang, Tianyue;Li, Shumei;Tian, Junzhang
通讯作者：
Tian, Junzhang
DOI：
10.1016/j.clinph.2011.06.018
发表时间：
2012-02
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Caporro M;Haneef Z;Yeh HJ;Lenartowicz A;Buttinelli C;Parvizi J;Stern JM
通讯作者：
Stern JM
DOI：
10.1007/s11548-008-0167-z
发表时间：
2008
影响因子：
3
作者：
V. Tuna;MS Çolak;H. Ulusoy;M. Kosucu;MZ Delago;P. Aliaga;M. Bandeira;CA Teixeira;FJ Ropero;S. Taniguchi
通讯作者：
V. Tuna;MS Çolak;H. Ulusoy;M. Kosucu;MZ Delago;P. Aliaga;M. Bandeira;CA Teixeira;FJ Ropero;S. Taniguchi