Sleep spindles predict stress-related increases in sleep disturbances.
Sleep spindles predict stress-related increases in sleep disturbances.
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DOI：
10.3389/fnhum.2015.00068
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发表时间：
2015
影响因子：
2.9
通讯作者：
Gouin JP
中科院分区：
文献类型：
--
作者：
Dang-Vu TT;Salimi A;Boucetta S;Wenzel K;O'Byrne J;Brandewinder M;Berthomier C;Gouin JP
背景和目的：诱发因素使某些人患失眠症的风险更高，特别是在有压力的生活事件等突发条件的情况下。睡眠纺锤波在保持睡眠连续性方面发挥着重要作用。因此，较低的纺锤体密度可能构成睡眠对压力反应的客观诱发因素。因此，本研究的目的是评估基线睡眠纺锤波密度和失眠症状的预期变化之间的关系，以应对标准化的学术压力。研究方法：12名健康的学生在学期开始时的一段较低压力期间进行了多导睡眠图记录，沿着使用失眠严重程度指数（ISI）评估失眠投诉。他们在学期末完成了第二次ISI评估，这段时间正好是期末考试的前一周，因此压力更大。纺锤体密度，振幅，持续时间和频率，以及西格玛功率计算从C4-O2脑电图推导N2-N3阶段的非快速眼动（NREM）睡眠，整个晚上和每个NREM睡眠期。为了测试纺锤体密度与学习压力引起的失眠症状变化之间的关系，将基线时的纺锤体测量值与整个学期的ISI变化相关联。结果如下：纺锤体密度（以及纺锤体振幅和西格玛功率），特别是在第一个NREM睡眠期，与ISI的变化呈负相关（p < 0.05）。结论：较低的纺锤波活动，特别是在夜晚开始时，前瞻性地预测了对压力的反应，失眠症状会增加。这一结果表明，睡眠纺锤波活动的个体差异有助于在面对沉淀因素时对睡眠障碍的差异脆弱性。
Background and Aim: Predisposing factors place certain individuals at higher risk for insomnia, especially in the presence of precipitating conditions such as stressful life events. Sleep spindles have been shown to play an important role in the preservation of sleep continuity. Lower spindle density might thus constitute an objective predisposing factor for sleep reactivity to stress. The aim of this study was therefore to evaluate the relationship between baseline sleep spindle density and the prospective change in insomnia symptoms in response to a standardized academic stressor. Methods: Twelve healthy students had a polysomnography recording during a period of lower stress at the beginning of the academic semester, along with an assessment of insomnia complaints using the insomnia severity index (ISI). They completed a second ISI assessment at the end of the semester, a period coinciding with the week prior to final examinations and thus higher stress. Spindle density, amplitude, duration, and frequency, as well as sigma power were computed from C4–O2 electroencephalography derivation during stages N2–N3 of non-rapid-eye-movement (NREM) sleep, across the whole night and for each NREM sleep period. To test for the relationship between spindle density and changes in insomnia symptoms in response to academic stress, spindle measurements at baseline were correlated with changes in ISI across the academic semester. Results: Spindle density (as well as spindle amplitude and sigma power), particularly during the first NREM sleep period, negatively correlated with changes in ISI (p < 0.05). Conclusion: Lower spindle activity, especially at the beginning of the night, prospectively predicted larger increases in insomnia symptoms in response to stress. This result indicates that individual differences in sleep spindle activity contribute to the differential vulnerability to sleep disturbances in the face of precipitating factors.
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影响因子：
4.8
作者：
Drake, Christopher L.;Jefferson, Catherine;Roth, Thomas
通讯作者：
Roth, Thomas
影响因子：
4.4
作者：
Fernandez-Mendoza, Julio;Shaffer, Michele L.;Vela-Bueno, Antonio
通讯作者：
Vela-Bueno, Antonio
影响因子：
3.3
作者：
Fernandez-Mendoza, Julio;Vela-Bueno, Antonio;Jose De la Cruz-Troca, Juan
通讯作者：
Jose De la Cruz-Troca, Juan
影响因子：
5.7
作者：
De Gennaro, L;Ferrara, M;Bertini, M
通讯作者：
Bertini, M
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.