Effect of brain-to-skull conductivity ratio on EEG source localization accuracy.

Effect of brain-to-skull conductivity ratio on EEG source localization accuracy.
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脑-颅骨电导率比对脑电图源定位精度的影响

DOI:
10.1155/2013/459346
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发表时间:
2013
影响因子:
--
通讯作者:
Ren D
Ren D
中科院分区:
生物学3区
文献类型:
--
作者:
Wang G;Ren D

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本研究的目的是探讨脑-颅电导率比(BSCR)对脑电源定位精度的影响。在这项研究中,我们评估了四个BSCR:15,20,25和80,这主要是根据文献进行讨论。头皮EEG信号由每个皮层偶极子源的BSCR相关的前向计算产生。然后,对于每个头皮EEG测量,进行源重构以通过实际BSCR和误指定的BSCR来识别估计的偶极子源。将估计的偶极子源与模拟的偶极子源进行比较,以评估EEG源定位精度。在考虑无噪声EEG测量的情况下,当使用实际BSCR时,平均定位误差近似等于零。错误指定的BSCR导致大量的定位误差,范围从2到16 mm。当考虑噪声污染的EEG测量时,尽管在逆计算中使用了BSCR,但平均定位误差范围为8至18 mm。研究结果表明,在脑电源重构中,脑电源的定位精度对脑电源的BSCR敏感,当脑电源的实际BSCR与高信噪比的头皮脑电信号结合使用时,可以准确定位脑电源的活动。
The goal of this study was to investigate the influence of the brain-to-skull conductivity ratio (BSCR) on EEG source localization accuracy. In this study, we evaluated four BSCRs: 15, 20, 25, and 80, which were mainly discussed according to the literature. The scalp EEG signals were generated by BSCR-related forward computation for each cortical dipole source. Then, for each scalp EEG measurement, the source reconstruction was performed to identify the estimated dipole sources by the actual BSCR and the misspecified BSCRs. The estimated dipole sources were compared with the simulated dipole sources to evaluate EEG source localization accuracy. In the case of considering noise-free EEG measurements, the mean localization errors were approximately equal to zero when using actual BSCR. The misspecified BSCRs resulted in substantial localization errors which ranged from 2 to 16 mm. When considering noise-contaminated EEG measurements, the mean localization errors ranged from 8 to 18 mm despite the BSCRs used in the inverse calculation. The present results suggest that the localization accuracy is sensitive to the BSCR in EEG source reconstruction, and the source activity can be accurately localized when the actual BSCR and the EEG scalp signals with high signal-to-noise ratio (SNR) are used.
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