Effects of intermittent (5:2) or continuous energy restriction on basal and postprandial metabolism: a randomised study in normal-weight, young participants.
Effects of intermittent (5:2) or continuous energy restriction on basal and postprandial metabolism: a randomised study in normal-weight, young participants.
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DOI：
10.1038/s41430-021-00909-2
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发表时间：
2022-01
影响因子：
4.7
通讯作者：
Taylor MA
中科院分区：
文献类型：
--
作者：
Gao Y;Tsintzas K;Macdonald IA;Cordon SM;Taylor MA
间歇性能量限制（IER）可以克服连续能量限制（CER）长期坚持不良的问题，从而减轻体重。我们比较了 IER 与 CER 对代谢健康参与者的空腹和餐后代谢和食欲的影响，其中超重不会混淆内在代谢差异。在一项为期 2 周的随机平行试验中，16 名健康体重的年轻参与者被分配到 CER（比估计能量需求 (EER) 低 20%）或 5:2 IER（非连续 2 天低于 EER 70%；每周 5 天处于 EER）。在液体早餐之前和之后 3 小时评估代谢和食欲调节标志物；随后是随意享用的午餐；干预前和干预后。两组体重减轻相似：5:2 IER 为 -2.5 (95% CI, -3.4, -1.6) kg，CER 为 -2.3 (-2.9, -1.7) kg。血清胰岛素、血糖或主观食欲评级的餐后增量曲线下面积在各组之间没有差异。与 CER 相比，5:2 IER 导致空腹血糖浓度降低（治疗与时间的相互作用，P = 0.018，η2p = 0.14）。同样，与 CER 相比，5:2 IER 后空腹综合食欲评分也出现了有益的变化（治疗与时间的相互作用，P = 0.0003，η2p = 0.35）。治疗之间的餐后胰岛素、血糖或食欲反应没有显着差异。然而，5:2 IER 可以更大程度地改善空腹血糖，并改善空腹主观食欲评级。
Intermittent energy restriction (IER) may overcome poor long-term adherence with continuous energy restriction (CER), for weight reduction. We compared the effects of IER with CER for fasting and postprandial metabolism and appetite in metabolically healthy participants, in whom excess weight would not confound intrinsic metabolic differences. In a 2-week randomised, parallel trial, 16 young, healthy-weight participants were assigned to either CER (20% below estimated energy requirements (EER)) or 5:2 IER (70% below EER on 2 non-consecutive days; 5 days at EER, per week). Metabolic and appetite regulation markers were assessed before and for 3 h after a liquid breakfast; followed by an ad libitum lunch; pre- and post-intervention. Weight loss was similar in both groups: −2.5 (95% CI, −3.4, −1.6) kg for 5:2 IER vs. −2.3 (−2.9, −1.7) kg for CER. There were no differences between groups for postprandial incremental area under the curve for serum insulin, blood glucose or subjective appetite ratings. Compared with CER, 5:2 IER led to a reduction in fasting blood glucose concentrations (treatment-by-time interaction, P = 0.018, η2p = 0.14). Similarly, compared with CER, there were beneficial changes in fasting composite appetite scores after 5:2 IER (treatment-by-time interaction, P = 0.0003, η2p = 0.35). There were no significant differences in postprandial insulinaemic, glycaemic or appetite responses between treatments. However, 5:2 IER resulted in greater improvements in fasting blood glucose, and beneficial changes in fasting subjective appetite ratings.
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影响因子：
37.8
作者：
Jensen MD;Ryan DH;Apovian CM;Ard JD;Comuzzie AG;Donato KA;Hu FB;Hubbard VS;Jakicic JM;Kushner RF;Loria CM;Millen BE;Nonas CA;Pi-Sunyer FX;Stevens J;Stevens VJ;Wadden TA;Wolfe BM;Yanovski SZ;Jordan HS;Kendall KA;Lux LJ;Mentor-Marcel R;Morgan LC;Trisolini MG;Wnek J;Anderson JL;Halperin JL;Albert NM;Bozkurt B;Brindis RG;Curtis LH;DeMets D;Hochman JS;Kovacs RJ;Ohman EM;Pressler SJ;Sellke FW;Shen WK;Smith SC Jr;Tomaselli GF;American College of Cardiology/American Heart Association Task Force on Practice Guidelines;Obesity Society
通讯作者：
Obesity Society
影响因子：
3.6
作者：
Antoni, Rona;Johnston, Kelly L.;Robertson, M. Denise
通讯作者：
Robertson, M. Denise
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
影响因子：
3.2
作者：
Henry, CJK
通讯作者：
Henry, CJK
影响因子：
--
作者：
Kivipelto, M;Ngandu, T;Nissinen, A
通讯作者：
Nissinen, A