The identification of attractive volatiles in aged male mouse urine.
The identification of attractive volatiles in aged male mouse urine.
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老年雄性小鼠尿液中有吸引力的挥发物的鉴定。
DOI：
10.1093/chemse/bjn045
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发表时间：
2008
期刊：
影响因子：
3.5
通讯作者：
Hiroshi Izumi
中科院分区：
文献类型：
--
作者：
K. Osada;T. Tashiro;K. Mori;Hiroshi Izumi
在许多物种中，年长的雄性往往是首选的配偶，因为他们携带的“好”基因可以解释他们的生存能力。在一些严重依赖化学通讯的动物中，包括老鼠，有迹象表明动物的年龄可以通过气味来确定。为了鉴定老年雄性小鼠尿液中的引诱剂，进行了化学和行为研究。我们在此表明，相对于成年雄性小鼠，老年小鼠具有更高水平的3，4-脱氢-外-短孢菌素（DB）、2-仲丁基-4，5-二氢噻唑（BT）和2-异丙基-4，5-二氢噻唑（IT）以及更低水平的6-羟基-6-甲基-3-庚酮。我们还表明，吸引力的女性男性老鼠尿液的气味是更大的尿液是从老年男性。然而，老年尿液气味的吸引力被成年和老年小鼠尿液的超滤所抵消。当DB、BT和IT加入到成人尿液中时，尿液的吸引力增强。我们的研究结果表明，近亲繁殖的老年雄性小鼠开发的老化气味，是有吸引力的雌性小鼠在实验环境中，这种吸引力是由于增加小鼠信息素信号。
In many species, older males are often preferred mates because they carry "good" genes that account for their viability. In some animals, including mice, which rely heavily on chemical communication, there is some indication that an animal's age can be determined by its scent. In order to identify the attractants in aged male mouse urine, chemical and behavioral studies were performed. We herein show that aged mice have higher levels of 3,4-dehydro-exo- brevicomin (DB), 2-sec-butyl-4,5-dihydrothiazole (BT), and 2-isopropyl-4,5-dihydrothiazole (IT) and a lower level of 6-hydroxy-6-methyl-3-heptanone relative to adult male mice. We also demonstrate that the attraction of females to the odor of male mouse urine is greater when the urine is from aged males. However, the attraction of aged urine odor was offset by the ultrafiltration of adult and aged mouse urine. When DB, BT, and IT were added to adult urine, the attraction of the urine was enhanced. Our results suggest that inbred aged male mice develop an aging odor that is attractive to female mice in an experimental setting and that this attraction is due to increased mouse pheromone signaling.
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影响因子：
--
作者：
Novotny, MV;Jemiolo, B;Carmack, M
通讯作者：
Carmack, M
衰老小鼠的睾丸功能和性活动。
DOI：
10.1152/ajpendo.1984.247.5.e569
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Chubb,C;Desjardins,C
通讯作者：
Desjardins,C
DOI：
10.1073/pnas.94.6.2210
发表时间：
1997-03-18
影响因子：
11.1
作者：
Singer, AG;Beauchamp, GK;Yamazaki, K
通讯作者：
Yamazaki, K
长期用脱氢表雄酮治疗可抑制衰老 Sprague-Dawley 大鼠和 C57BL/6 小鼠蛋白尿的发生。
DOI：
10.1093/geronj/41.4.433
发表时间：
1986
期刊：
Journal of gerontology
影响因子：
--
作者：
Pashko,LL;Fairman,DK;Schwartz,AG
通讯作者：
Schwartz,AG