Macromolecule-suppressed GABA measurements correlate more strongly with behavior than macromolecule-contaminated GABA+ measurements.
Macromolecule-suppressed GABA measurements correlate more strongly with behavior than macromolecule-contaminated GABA+ measurements.
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DOI：
10.1016/j.brainres.2018.09.021
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发表时间：
2018-12-15
期刊：
影响因子：
2.9
通讯作者：
Puts NAJ
中科院分区：
文献类型：
--
作者：
Mikkelsen M;Harris AD;Edden RAE;Puts NAJ
抑制性神经递质γ-氨基丁酸（GABA）是视觉定向、振动触觉频率和振幅辨别的神经元基础。先前的研究已经证明，视觉和振动触觉心理物理学任务的表现与体内测量的“GABA+”水平相关-GABA基本上被大分子（MM）信号污染的测量。在这里，我们确定这些先前的发现确实是由该信号的GABA部分驱动的。编辑的磁共振波谱（MRS）被用来测量GABA与MM抑制和没有感觉运动（SM 1）和枕叶皮质在14个健康的男性成年人。志愿者还接受了心理物理实验，以评估他们的表现，视觉方向的歧视和振动触觉幅度和频率的歧视。我们发现，MM抑制GABA水平与振动触觉的个体差异更密切相关，（在SM 1 GABA的情况下;振幅：r =-0.63，p = 0.03;频率：r =-0.62，p = 0.02）和视觉定向（在枕叶GABA的情况下; r =-0.59，p = 0.05）识别阈值高于MM污染的GABA水平（振动触觉振幅：r =-0.36，p = 0.30;振动触觉频率：r =-0.53，p = 0.09;视觉定向：r = 0.21，p = 0.55）。这些发现进一步支持了这样的观点，即通过编辑MRS获得的内源性GABA的测量可以有效地探测人类的神经化学-行为关系。此外，本研究中使用的GABA的更具体的测量提供了更高的统计能力来观察这些区域特定的关系。
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in vivo measurements of “GABA+” levels – a measure of GABA substantially contaminated by a macromolecular (MM) signal. Here, we establish that these prior finding are indeed driven by the GABA fraction of that signal. Edited magnetic resonance spectroscopy (MRS) was used to measure GABA with and without MM suppression in the sensorimotor (SM1) and occipital cortices in fourteen healthy male adults. Volunteers also underwent psychophysical experiments to assess their performance on visual orientation discrimination and vibrotactile amplitude and frequency discrimination. We show that MM-suppressed GABA levels correlate more strongly with individual differences in vibrotactile (in the case of SM1 GABA; amplitude: r = –0.63, p = 0.03; frequency: r = –0.62, p = 0.02) and visual orientation (in the case of occipital GABA; r = –0.59, p = 0.05) discrimination thresholds than GABA levels contaminated by MM (vibrotactile amplitude: r = –0.36, p = 0.30; vibrotactile frequency: r = –0.53, p = 0.09; visual orientation: r = 0.21, p = 0.55). These findings further support the view that measurements of endogenous GABA acquired with edited MRS can usefully probe neurochemical–behavioral relationships in humans. Moreover, the more specific measurement of GABA used in this study provides increased statistical power to observe these regionally specific relationships.
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DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
影响因子：
2.5
作者：
MCCORMICK, DA
通讯作者：
MCCORMICK, DA
影响因子：
10.6
作者：
Epperson, CN;O'Malley, S;Mason, GF
通讯作者：
Mason, GF
影响因子：
2.5
作者：
DYKES, RW;LANDRY, P;HICKS, TP
通讯作者：
HICKS, TP
DOI：
10.1016/j.pscychresns.2017.12.005
发表时间：
2018-03-30
期刊：
Psychiatry research. Neuroimaging
影响因子：
--
作者：
Mahone EM;Puts NA;Edden RAE;Ryan M;Singer HS
通讯作者：
Singer HS