GABA and glutamate in children with Tourette syndrome: A (1)H MR spectroscopy study at 7T.
GABA and glutamate in children with Tourette syndrome: A (1)H MR spectroscopy study at 7T.
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DOI：
10.1016/j.pscychresns.2017.12.005
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发表时间：
2018-03-30
期刊：
影响因子：
--
通讯作者：
Singer HS
中科院分区：
文献类型：
--
作者：
Mahone EM;Puts NA;Edden RAE;Ryan M;Singer HS
多发性抽动症(TS)的特征是出现慢性、波动的运动和语音。这些运动的潜在神经生物学基础被假设涉及皮质-纹状体-丘脑-皮质(CSTC)通路。这些回路中的两种主要神经递质是γ-氨基丁酸和谷氨酸。75名年龄在5-12岁的受试者(32名患有TS，43名对照组)在7T完成了1HMRS，测量了背外侧额前皮质(DLPFC)、腹内侧额前皮质(VMPFC)、运动前皮质(PMC)和纹状体的GABA和谷氨酸，并用LC模型对代谢物进行了定量。参与者还完成了强调抑制控制的神经心理学评估。参与者对扫描的耐受性很好。综合所有感兴趣区，与对照组相比，TS组的谷氨酸水平显著升高，但观察到的GABA水平没有显著差异。ROI分析显示，TS组的PMC谷氨酸显著增加。在患有TS的儿童中，PMC谷氨酸水平的增加与选择性运动抑制的改善有关；然而，谷氨酸或GABA水平与抽动严重程度之间没有明显的关联。长期以来，多巴胺能系统一直被认为在TS中起主导作用。然而，越来越多的证据表明，其他神经递质系统也参与其中。在7T时使用1H MRS获得的数据支持TS儿童习惯行为相关CSTC通路中谷氨酸的变化。
Tourette syndrome (TS) is characterized by presence of chronic, fluctuating motor and phonic tics. The underlying neurobiological basis for these movements is hypothesized to involve cortical-striatal-thalamo-cortical (CSTC) pathways. Two major neurotransmitters within these circuits are γ-aminobutyric acid (GABA) and glutamate. Seventy-five participants (32 with TS, 43 controls) ages 5–12 years completed 1H MRS at 7 T. GABA and glutamate were measured in dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex (VMPFC), premotor cortex (PMC), and striatum, and metabolites quantified using LCModel. Participants also completed neuropsychological assessment emphasizing inhibitory control. Scans were well tolerated by participants. Across ROIs combined, glutamate was significantly higher in the TS group, compared to controls, with no significant group differences in GABA observed. ROI analyses revealed significantly increased PMC glutamate in the TS group. Among children with TS, increased PMC glutamate was associated with improved selective motor inhibition; however, no significant associations were identified between levels of glutamate or GABA and tic severity. The dopaminergic system has long been considered to have a dominant role in TS. Accumulating evidence, however, suggests involvement of other neurotransmitter systems. Data obtained using 1H MRS at 7 T supports alteration of glutamate within habitual behavior-related CSTC pathways of children with TS.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.3174/ajnr.a4547
发表时间：
2016-03
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
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作者：
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
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