Endogenous retroviruses mobilized during friend murine leukemia virus infection.
Endogenous retroviruses mobilized during friend murine leukemia virus infection.
复制标题
DOI：
10.1016/j.virol.2016.07.009
复制
发表时间：
2016-12
期刊：
影响因子：
3.7
通讯作者：
Evans, Leonard H.
中科院分区：
文献类型：
--
作者：
Boi, Stefano;Rosenke, Kyle;Hansen, Ethan;Hendrick, Duncan;Malik, Frank;Evans, Leonard H.
We have demonstrated in a mouse model that infection with a retrovirus can lead not only to the generation of recombinants between exogenous and endogenous gammaretrovirus, but also to the mobilization of endogenous proviruses by pseudotyping entire polytropic proviral transcripts and facilitating their infectious spread to new cells. However, the frequency of this occurrence, the kinetics, and the identity of mobilized endogenous proviruses was unclear. Here we find that these mobilized transcripts are detected after only one day of infection. They predominate over recombinant polytropic viruses early in infection, persist throughout the course of disease and are comprised of multiple different polytropic proviruses. Other endogenous retroviral elements such as intracisternal A particles (IAPs) were not detected. The integration of the endogenous transcripts into new cells could result in loss of transcriptional control and elevated expression which may facilitate pathogenesis, perhaps by contributing to the generation of polytropic recombinant viruses.
登录
查看更多内容
遗传机制的解剖，涉及与鼠狼疮炎有关的血清逆转录病毒GP70的表达。
影响因子：
4.4
作者：
Baudino, Lucie;Yoshinobu, Kumiko;Morito, Naoki;Kikuchi, Shuichi;Fossati-Jimack, Liliane;Morley, Bernard J.;Vyse, Timothy J.;Hirose, Sachiko;Jorgensen, Trine N.;Tucker, Rebecca M.;Roark, Christina L.;Kotzin, Brian L.;Evans, Leonard H.;Izui, Shozo
通讯作者：
Izui, Shozo
影响因子：
2.5
作者：
FRANKEL, WN;COFFIN, JM
通讯作者：
COFFIN, JM
影响因子：
5.4
作者：
EVANS, LH;CLOYD, MW
通讯作者：
CLOYD, MW
影响因子：
5.4
作者：
ADACHI, A;SAKAI, K;ISHIMOTO, A
通讯作者：
ISHIMOTO, A
影响因子：
64.5
作者：
DONOGHUE, DJ;ROTHENBERG, E;SHARP, PA
通讯作者：
SHARP, PA