Exercise habits and C-reactive protein may predict development of spinal immobility in patients with ankylosing spondylitis.
Exercise habits and C-reactive protein may predict development of spinal immobility in patients with ankylosing spondylitis.
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DOI：
10.1007/s10067-018-4195-y
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发表时间：
2018-10
影响因子：
3.4
通讯作者：
Wållberg-Jonsson S
中科院分区：
文献类型：
--
作者：
Sundström B;Ljung L;Wållberg-Jonsson S
为了评估AS患者长期临床研究中脊柱不动的预测因素，对54例强直性脊柱炎患者（41例男性，随访结束时平均年龄54.7岁）的脊柱活动度年度临床测量数据与生活方式因素相关数据以及既往横断面研究的实验室测量数据进行了共同分析。根据最近发表的年龄、性别和身长特异性参考区间对脊柱不动进行分级。运动习惯和高敏C反应蛋白（hsCRP）与亚正常脊柱不动的发生独立相关（p = 0.019和p = 0.021）。在多元回归模型中，约25%的脊柱不动可归因于疾病持续时间（p ≤ 0.011）、hsCRP水平（p ≤ 0.004）和休闲时间的运动（p ≤ 0.019）。研究队列中hsCRP的平均浓度为4.2 mg/L（范围为0.2-8.4 mg/L）。Bath强直性脊柱炎疾病活动指数（BASDAI）、红细胞沉降率（ESR）和工作时的体力活动与脊柱不动无关。结果表明，运动习惯可能对预防AS中脊柱不动的发展产生影响，而与疾病持续时间和炎症无关。这与风湿病学家、卫生专业人员和患者长期临床经验积累的知识一致。因此，运动仍应是AS患者非药物治疗和自我护理的重要组成部分。此外，适度的炎症活动，测量为轻微升高的hsCRP浓度，似乎会影响随后的脊柱不动性AS。
To assess predictors for spinal immobility in a long-term clinical study of patients with AS, data from annual clinical measurements of spinal mobility in 54 patients (41 men, mean of age at end of follow-up 54.7 years) with ankylosing spondylitis were co-analysed with data regarding lifestyle factors as well as laboratory measurements from a previous cross-sectional study. Spinal immobility was graded on the basis of recently published age-, sex- and length-specific reference intervals. Exercise habits and high-sensitivity C-reactive protein (hsCRP) were independently associated with the development of subnormal spinal immobility (p = 0.019 and p = 0.021). In multiple regression models, approximately 25% of the spinal immobility could be attributed to disease duration (p ≤ 0.011), levels of hsCRP (p ≤ 0.004) and exercise in leisure time (p ≤ 0.019). The mean concentration of hsCRP was 4.2 mg/L (range 0.2–8.4 mg/L) in the study cohort. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR) and physical activity at work were not associated with spinal immobility. The results indicate that exercise habits may have an impact in preventing the development of spinal immobility in AS independently of disease duration and inflammation. This corresponds well with the accumulated knowledge from long-term clinical experience among rheumatologists, health professionals and patients. Consequently, exercise should remain an important part of the non-pharmacological treatment and self-care for patients with AS. Furthermore, modest inflammatory activity, measured as a slightly elevated hsCRP concentration, appears to affect subsequent spinal immobility in AS.
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影响因子：
3.9
作者：
Sundstrom, Bjorn;Johansson, Gunnar;Wallberg-Jonsson, Solveig
通讯作者：
Wallberg-Jonsson, Solveig
影响因子：
2.1
作者：
Waldner, A;Cronstedt, H;Stenstrom, CH
通讯作者：
Stenstrom, CH
影响因子：
27.4
作者：
Maksymowych, Walter P.;Morency, Nathalie;Lambert, Robert G.
通讯作者：
Lambert, Robert G.
影响因子：
2.1
作者：
Cronstedt, H;Waldner, A;Stenström, CH
通讯作者：
Stenström, CH
影响因子：
27.4
作者：
Ramiro, Sofia;van Tubergen, Astrid;Landewe, Robert
通讯作者：
Landewe, Robert