Spinogenesis and Pruning in the Anterior Ventral Inferotemporal Cortex of the Macaque Monkey: An Intracellular Injection Study of Layer III Pyramidal Cells.
Spinogenesis and Pruning in the Anterior Ventral Inferotemporal Cortex of the Macaque Monkey: An Intracellular Injection Study of Layer III Pyramidal Cells.
复制标题
DOI：
10.3389/fnana.2011.00042
复制
发表时间：
2011
影响因子：
2.9
通讯作者：
Fujita I
中科院分区：
文献类型：
--
作者：
Elston GN;Oga T;Okamoto T;Fujita I
猕猴皮层不同区域锥体细胞的生长和成熟速度不同。特别是，在第三层细胞的基底树突状树的生长、分支、脊柱发生和修剪的时间和大小上，不同区域之间的差异已经被报道。目前可用的数据表明，这些不同的生长特征反映了这些细胞在成人大脑中所执行的功能类型。然而，到目前为止，研究只集中在相对较少的皮质区域。为了更好地了解大脑皮层的发育趋势，本研究对细胞结构区（TEav）前腹部第三层锥体细胞树突状树的生长进行了量化。我们量化了从出生后第2天（PND2）到4岁半的树突的生长和分支，以及棘的发生和修剪。我们发现，从PND2到7月龄，树突树的大小增加，然后变得更小。从PND2到成年，树突树的分支越来越多。从PND2到3.5个月大，锥体细胞基底树突状树的脊柱数量增加了两倍，然后到成年期脊柱数量净减少10%。因此，颞下皮层前腹侧部分的第三层锥体细胞的生长特征与其他与视觉处理相关的皮层区域不同。
Pyramidal cells grow and mature at different rates among different cortical areas in the macaque monkey. In particular, differences across the areas have been reported in both the timing and magnitude of growth, branching, spinogenesis, and pruning in the basal dendritic trees of cells in layer III. Presently available data suggest that these different growth profiles reflect the type of functions performed by these cells in the adult brain. However, to date, studies have focused on only a relatively few cortical areas. In the present investigation we quantified the growth of the dendritic trees of layer III pyramidal cells in the anterior ventral portion of cytoarchitectonic area TE (TEav) to better comprehend developmental trends in the cerebral cortex. We quantified the growth and branching of the dendrities, and spinogenesis and pruning of spines, from post-natal day 2 (PND2) to four and a half years of age. We found that the dendritic trees increase in size from PND2 to 7 months of age and thereafter became smaller. The dendritic trees became increasingly more branched from PND2 into adulthood. There was a two-fold increase in the number of spines in the basal dendritic trees of pyramidal cells from PND2 to 3.5 months of age and then a 10% net decrease in spine number into adulthood. Thus, the growth profile of layer III pyramidal cells in the anterior ventral portion of the inferotemporal cortex differs to that in other cortical areas associated with visual processing.
登录
查看更多内容
影响因子：
56.9
作者：
LEWIS, ME;MISHKIN, M;PERT, A
通讯作者：
PERT, A
影响因子：
1.7
作者：
BACHEVALIER, J;BRICKSON, M;HAGGER, C
通讯作者：
HAGGER, C
影响因子：
2.5
作者：
HOF, PR;NIMCHINSKY, EA;MORRISON, JH
通讯作者：
MORRISON, JH
影响因子：
2.6
作者：
HUTTENLOCHER, PR
通讯作者：
HUTTENLOCHER, PR
影响因子：
3.4
作者：
Kondo, H;Tanaka, K;Jones, EG
通讯作者：
Jones, EG