β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.
β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.
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β-肾上腺素能受体阻断会损害年轻男性的冠状动脉运动充血，但不会损害老年男性。
DOI：
10.1152/ajpheart.00584.2014
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Muller,MatthewD
中科院分区：
文献类型：
--
作者：
Ross,AmandaJ;Gao,Zhaohui;Pollock,JonathanP;Leuenberger,UrsA;Sinoway,LawrenceI;Muller,MatthewD
冠状动脉疾病患者对生理应激的冠状动脉舒张反应减弱，这部分归因于β-肾上腺素能受体（β-AR）介导的机制。β-AR是否会导致健康衰老时冠状动脉血管舒张功能受损尚不清楚。本研究旨在探讨β-AR在健康人冠状动脉运动充血中的作用。6名年轻男性（26 ± 1岁）和7名老年男性（67 ± 4岁）在接受静脉注射普萘洛尔（β-AR拮抗剂）后，以30%最大自主收缩进行等长握力运动2分钟，未接受任何治疗。输注β-AR激动剂异丙肾上腺素以确认β-AR阻断。连续监测血压和心率，经胸多普勒超声心动图测量冠状动脉血流速度（CBV，左前降支）。与年轻男性相比，老年男性等长收缩运动的ΔCBV降低（3.8 ± 1.3 vs 9.7 ± 2.1 cm/s，P= 0.02）。普萘洛尔降低了年轻男性在最大握力运动时的ΔCBV（9.7 ± 2.1 vs. 2.7 ± 0.9 cm/s，P= 0.008）。然而，普萘洛尔对老年男性的ΔCBV没有影响（3.8 ± 1.3 vs. 4.2 ± 1.9 cm/s，P= 0.9）。老年男性在低剂量异丙肾上腺素作用下，冠脉充血也减弱。这些数据表明，β-AR对健康老年男性冠状动脉血流的控制受损。
Patients with coronary artery disease have attenuated coronary vasodilator responses to physiological stress, which is partially attributed to a β-adrenergic receptor (β-AR)-mediated mechanisms. Whether β-ARs contribute to impaired coronary vasodilation seen with healthy aging is unknown. The purpose of this study was to investigate the role of β-ARs in coronary exercise hyperemia in healthy humans. Six young men (26 ± 1 yr) and seven older men (67 ± 4 yr) performed isometric handgrip exercise at 30% maximal voluntary contraction for 2 min after receiving intravenous propranolol, a β-AR antagonist, and no treatment. Isoproterenol, a β-AR agonist, was infused to confirm the β-AR blockade. Blood pressure and heart rate were monitored continuously, and coronary blood flow velocity (CBV, left anterior descending artery) was measured by transthoracic Doppler echocardiography. Older men had an attenuated ΔCBV to isometric exercise (3.8 ± 1.3 vs. 9.7 ± 2.1 cm/s,P= 0.02) compared with young men. Propranolol decreased the ΔCBV at peak handgrip exercise in young men (9.7 ± 2.1 vs. 2.7 ± 0.9 cm/s,P= 0.008). However, propranolol had no effect on ΔCBV in older men (3.8 ± 1.3 vs. 4.2 ± 1.9 cm/s,P= 0.9). Older men also had attenuated coronary hyperemia to low-dose isoproterenol. These data indicate that β-AR control of coronary blood flow is impaired in healthy older men.
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DOI：
10.1096/fasebj.26.1_supplement.864.15
发表时间：
2012
期刊：
The FASEB Journal
影响因子：
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作者：
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影响因子：
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3
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