High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects.
High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects.
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DOI：
10.1371/journal.pone.0165511
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kayama T
中科院分区：
文献类型：
--
作者：
Kohno K;Narimatsu H;Shiono Y;Suzuki I;Kato Y;Sho R;Otani K;Ishizawa K;Yamashita H;Kubota I;Ueno Y;Kato T;Fukao A;Kayama T
红细胞异常包括贫血和红细胞增多症，通常在一般临床环境中观察到。由于最近的研究报道脂联素对造血有负面影响，我们在1029名40岁及以上的日本受试者（477名男性和552名女性）中进行了一项前瞻性观察性研究，以评估贫血与脂联素以及其他参数之间的关系。在基线和5至7年后（随访）进行身体测量，血液检查和营养摄入研究。高血清脂联素水平男性的血红蛋白（Hb）和红细胞压积（Hct）水平在随访时低于基线水平。多元回归分析显示，年龄、体重指数、脂联素和谷氨酰胺转氨酶与红细胞相关变量（红细胞、Hb和Hct）在男性和女性中均显著相关（P <0.05）。Logistic回归分析显示，脂联素、空腹血糖和β-利钠肽是男性贫血的重要危险因素，血尿素氮和淀粉酶是女性贫血的重要危险因素。体格特征和营养素摄入不是贫血的危险因素。我们的研究表明，在临床和流行病学上，高血清脂联素水平降低红细胞相关变量的数量，是日本男性贫血的危险因素。
Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.
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影响因子：
3.1
作者：
Kohno, Kei;Narimatsu, Hiroto;Kato, Takeo
通讯作者：
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影响因子：
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作者：
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影响因子：
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8.7
作者：
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DOI：
10.1093/gerona/63.5.447
发表时间：
2008-05-01
影响因子：
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作者：
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