Quantitative neuropathology associated with chronic manganese exposure in South African mine workers.
Quantitative neuropathology associated with chronic manganese exposure in South African mine workers.
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DOI：
10.1016/j.neuro.2013.12.008
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发表时间：
2014-12
期刊：
影响因子：
3.4
通讯作者：
Racette, Brad A.
中科院分区：
文献类型：
--
作者：
Gonzalez-Cuyar, Luis F.;Nelson, Gill;Criswell, Susan R.;Ho, Pokuan;Lonzanida, Jaymes A.;Checkoway, Harvey;Seixas, Noah;Gelman, Benjamin B.;Evanoff, Bradley A.;Murray, Jill;Zhang, Jing;Racette, Brad A.
锰 (Mn) 是一种常见的神经毒物，与临床综合征相关，包括与基底神经节相关的体征和症状。尽管通过分子和结构成像技术，在理解人类锰神经毒性的病理生理学方面取得了许多进展，但只有少数病例报告描述了相关的病理学发现，而且所有病例都发生在暴露于相对高水平锰的有症状受试者中。我们进行了一项探索性神经组织病理学研究，以调查南非锰矿工人与长期低水平锰暴露相关的纹状体（尾状核、壳核和苍白球）的变化。采用免疫组织化学技术对八名没有运动障碍临床证据的南非锰矿工人和八名年龄、种族、性别匹配的非锰矿工人的纹状体神经元和神经胶质成分的细胞密度进行了量化。锰矿工人苍白球外段和内段的平均小胶质细胞密度高于非锰矿工人[GPe：每个 HPF 分别有 1.33 和 0.87 个细胞（p=0.064）； GPi：每个 HPF 分别有 1.37 和 0.99 个细胞 (p=0.250)]。在锰矿工作的年数与 GPi 中的小胶质细胞密度显着相关（Spearman's rho 0.886；p=0.019）。锰矿工人各脑区星形胶质细胞与小胶质细胞的比例低于非锰矿工人的尾状核（7.80和14.68；p=0.025）、壳核（7.35和11.11；p=0.117）、GPe（10.60和16.10；p=0.091）和GPi（9.56和16.10；p=0.091）。 12.42；p=0.376)。未来的研究将需要在更大的锰矿工样本中纳入更详细的职业暴露，以证明锰暴露与这些病理结果之间的病因关系。
Manganese (Mn) is a common neurotoxicant associated with a clinical syndrome that includes signs and symptoms referable to the basal ganglia. Despite many advances in understanding the pathophysiology of Mn neurotoxicity in humans, with molecular and structural imaging techniques, only a few case reports describe the associated pathological findings, and all are in symptomatic subjects exposed to relatively high-level Mn. We performed an exploratory, neurohistopathological study to investigate the changes in the corpus striatum (caudate nucleus, putamen, and globus pallidus) associated with chronic low-level Mn exposure in South African Mn mine workers. Immunohistochemical techniques were used to quantify cell density of neuronal and glial components of the corpus striatum in eight South African Mn mine workers without clinical evidence of a movement disorder and eight age-race-gender matched, non-Mn mine workers. There was higher mean microglia density in Mn mine workers than non-Mn mine workers in the globus pallidus external and internal segments [GPe: 1.33 and 0.87 cells per HPF, respectively (p=0.064); GPi: 1.37 and 0.99 cells per HPF, respectively (p=0.250)]. The number of years worked in the Mn mines was significantly correlated with microglial density in the GPi (Spearman's rho 0.886; p=0.019). The ratio of astrocytes to microglia in each brain region was lower in the Mn mine workers than the non-Mn mine workers in the caudate (7.80 and 14.68; p=0.025), putamen (7.35 and 11.11; p=0.117), GPe (10.60 and 16.10; p=0.091) and GPi (9.56 and 12.42; p=0.376). Future studies incorporating more detailed occupational exposures in a larger sample of Mn mine workers will be needed to demonstrate an etiologic relationship between Mn exposure and these pathological findings.
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影响因子：
3.4
作者：
Nelson G;Criswell SR;Zhang J;Murray J;Racette BA
通讯作者：
Racette BA
DOI：
10.1080/15459620903454600
发表时间：
2010-01-01
影响因子：
2
作者：
Flynn, Michael R.;Susi, Pam
通讯作者：
Susi, Pam
影响因子：
3.4
作者：
Myers, JE;teWaterNaude, J;Thompson, ML
通讯作者：
Thompson, ML
影响因子：
4.9
作者：
Criswell SR;Perlmutter JS;Huang JL;Golchin N;Flores HP;Hobson A;Aschner M;Erikson KM;Checkoway H;Racette BA
通讯作者：
Racette BA
影响因子：
3.8
作者：
Milatovic, Dejan;Yin, Zhaobao;Aschner, Michael
通讯作者：
Aschner, Michael