Inhibitory activity of Sargassum hemiphyllum sulfated polysaccharide in arachidonic acid-induced animal models of inflammation.
Inhibitory activity of Sargassum hemiphyllum sulfated polysaccharide in arachidonic acid-induced animal models of inflammation.
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DOI：
10.1016/j.jfda.2014.05.004
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发表时间：
2015-03
影响因子：
3.6
通讯作者：
Chien, Shih-Yung
中科院分区：
文献类型：
--
作者：
Hwang, Pai-An;Hung, Yu-Lan;Chien, Shih-Yung
半叶马尾藻是台湾沿海常见的一种植物，在传统草药中被用作消炎剂。本研究旨在通过两种不同的小鼠模型评价半叶链球菌多糖(SHSP)的抗炎作用。在花生四烯酸诱导的耳部炎症灌胃和涂抹模型中，SHSP均可减少耳部肿胀和红斑。对髓过氧化物酶、一氧化氮、白细胞介素1β(IL-1β)、IL-6和肿瘤坏死因子-α的产生呈剂量依赖关系。组织学检查结果显示，三七总皂甙能减少炎症耳中性粒细胞的渗出面积。SHSP的抗炎活性已在体外得到证实。在这项研究中，从同一种棕色海藻中提取的SHSP在体内的口服和局部应用中都显示出抗炎活性。因此，SHSP可能在炎症性疾病的治疗中发挥作用。
Sargassum hemiphyllum is a common plant found on the coasts of Taiwan; it has been used as an anti-inflammatory agent in traditional herbal medicine. This study aimed to evaluate the anti-inflammatory effects of S. hemiphyllum sulfated polysaccharide (SHSP) using two different mouse models. In both arachidonic acid-induced ear inflammatory gavage and paint models, SHSP decreased ear swelling and erythema. In addition, SHSP decreased the production of myeloperoxidase, nitric oxide, interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α in a dose-dependent manner. Histological examination results showed that SHSP reduced the area of neutrophilic infiltration in inflamed ears. The anti-inflammatory activity of SHSP has already been demonstrated in vitro. In this study, SHSP extracted from the same species of brown seaweed exhibited anti-inflammatory activity in both oral and topical applications in vivo. Therefore, SHSP may play a role in the treatment of inflammatory diseases.
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影响因子：
4.3
作者：
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通讯作者：
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