Journey of mesenchymal stem cells for homing: strategies to enhance efficacy and safety of stem cell therapy.
Journey of mesenchymal stem cells for homing: strategies to enhance efficacy and safety of stem cell therapy.
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DOI：
10.1155/2012/342968
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发表时间：
2012
影响因子：
4.3
通讯作者：
Ra JC
中科院分区：
文献类型：
--
作者：
Kang SK;Shin IS;Ko MS;Jo JY;Ra JC
人类间充质干细胞（MSC）与人体内的其他细胞交流，并似乎响应细胞损伤的信号（称为归巢信号）而“归巢”到损伤区域。本文综述了目前对MSC归巢的研究状况，表明有利的细胞条件和体内环境有利于MSC迁移到体内损伤或损伤部位。我们回顾了目前对MSC迁移的理解，并讨论了增强MSC有效归巢的环境和细胞条件的策略。这可以允许MSC快速找到并迁移到受损组织，在那里它们可以最好地发挥由于改善归巢和MSC数量增加而产生的临床益处。
Human mesenchymal stem cells (MSCs) communicate with other cells in the human body and appear to “home” to areas of injury in response to signals of cellular damage, known as homing signals. This review of the state of current research on homing of MSCs suggests that favorable cellular conditions and the in vivo environment facilitate and are required for the migration of MSCs to the site of insult or injury in vivo. We review the current understanding of MSC migration and discuss strategies for enhancing both the environmental and cellular conditions that give rise to effective homing of MSCs. This may allow MSCs to quickly find and migrate to injured tissues, where they may best exert clinical benefits resulting from improved homing and the presence of increased numbers of MSCs.
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影响因子：
13.6
作者：
Ankrum J;Karp JM
通讯作者：
Karp JM
影响因子：
6.5
作者：
ALVAREZ, OM;MERTZ, PM;EAGLSTEIN, WH
通讯作者：
EAGLSTEIN, WH
影响因子：
4.8
作者：
BOURGUIGNON, GJ;BOURGUIGNON, LYW
通讯作者：
BOURGUIGNON, LYW
术语羊膜是多能间充质干细胞的高吞吐量来源，能够在体外分化为内皮细胞。
影响因子：
--
作者：
Alviano, Francesco;Fossati, Valentina;Marchionni, Cosetta;Arpinati, Mario;Bonsi, Laura;Franchina, Michele;Lanzoni, Giacomo;Cantoni, Silvia;Cavallini, Claudia;Bianchi, Francesca;Tazzari, Pier Luigi;Pasquinelli, Gianandrea;Foroni, Laura;Ventura, Carlo;Grossi, Alberto;Bagnara, Gian Paolo
通讯作者：
Bagnara, Gian Paolo
影响因子：
2.6
作者：
Ahmadi, Nafiseh;Razavi, Shahnaz;Oryan, Shahrbanoo
通讯作者：
Oryan, Shahrbanoo