Tissue linkage through adjoining basement membranes: The long and the short term of it.
Tissue linkage through adjoining basement membranes: The long and the short term of it.
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DOI：
10.1016/j.matbio.2018.05.009
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Sherwood DR
中科院分区：
文献类型：
--
作者：
Keeley DP;Sherwood DR
基底膜是包围大多数组织的薄而致密的细胞外基质。当邻近组织的脑转移瘤接触时，它们通常会彼此滑动，并将组织和器官分离成不同的区室。然而，在某些特定的区域，邻近组织的脑转移瘤连接起来，帮助组织结合在一起。这些脑内连接可以是短暂的，如在发育过程中的组织融合事件中，也可以是长期的，如涉及滤过的成人组织，包括血脑屏障和肾小球。这些连接在发育过程中的短暂性和成人组织过滤系统的复杂性阻碍了对并列脑转移如何紧密结合在一起的理解。然而，最近在秀丽隐杆线虫中发现的BM-BM粘附系统，称为B-LINK （BM连锁），揭示了新生组织粘附系统的细胞和细胞外基质成分。我们讨论了从研究秀丽隐杆线虫的B-LINK组织粘附系统中获得的见解，将这种粘附与果蝇和脊椎动物的其他BM-BM连接进行了比较，并概述了未来重要的方向，以阐明这种迷人的、鲜为人知的连接邻近组织的粘附模式。
Basement membranes (BMs) are thin dense sheets of extracellular matrix that surround most tissues. When the BMs of neighboring tissues come into contact, they usually slide along one another and act to separate tissues and organs into distinct compartments. However, in certain specialized regions, the BMs of neighboring tissues link, helping to bring tissues together. These BM connections can be transient, such as during tissue fusion events in development, or long-term, as with adult tissues involved with filtration, including the blood brain barrier and kidney glomerulus. The transitory nature of these connections in development and the complexity of tissue filtration systems in adults have hindered the understanding of how juxtaposed BMs fasten together. The recent identification of a BM-BM adhesion system in C. elegans, termed B-LINK (BM linkage), however, is revealing cellular and extracellular matrix components of a nascent tissue adhesion system. We discuss insights gained from studying the B-LINK tissue adhesion system in C. elegans, compare this adhesion with other BM-BM connections in Drosophila and vertebrates, and outline important future directions towards elucidating this fascinating and poorly understood mode of adhesion that joins neighboring tissues.
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影响因子：
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作者：
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