A review of β-amyloid neuroimaging in Alzheimer's disease.
A review of β-amyloid neuroimaging in Alzheimer's disease.
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DOI：
10.3389/fnins.2014.00327
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发表时间：
2014
影响因子：
4.3
通讯作者：
Egan GF
中科院分区：
文献类型：
--
作者：
Adlard PA;Tran BA;Finkelstein DI;Desmond PM;Johnston LA;Bush AI;Egan GF
Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing age is the greatest risk factor for developing AD, the number of those afflicted is expected to increase markedly with the aging of the world's population. The inability to definitively diagnose AD until autopsy remains an impediment to establishing effective targeted treatments. Neuroimaging has enabled in vivo visualization of pathological changes in the brain associated with the disease, providing a greater understanding of its pathophysiological development and progression. However, neuroimaging biomarkers do not yet offer clear advantages over current clinical diagnostic criteria for them to be accepted into routine clinical use. Nonetheless, current insights from neuroimaging combined with the elucidation of biochemical and molecular processes in AD are informing the ongoing development of new imaging techniques and their application. Much of this research has been greatly assisted by the availability of transgenic mouse models of AD. In this review we summarize the main efforts of neuroimaging in AD in humans and in mouse models, with a specific focus on β-amyloid, and discuss the potential of new applications and novel approaches.
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在阿尔茨海默氏病的转基因小鼠模型中，由T2加权，T2*加权和易感加权成像方法产生的淀粉样斑块对比的比较。
影响因子：
3.3
作者：
Chamberlain, Ryan;Reyes, Denise;Curran, Geoffrey L.;Marjanska, Malgorzata;Wengenack, Thomas M.;Poduslo, Joseph F.;Garwood, Michael;Jack, Clifford R., Jr.
通讯作者：
Jack, Clifford R., Jr.
影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
4.4
作者：
Borthakur, Arijitt;Gur, Tamar;Reddy, Ravinder
通讯作者：
Reddy, Ravinder
影响因子：
2.8
作者：
Brickman, Adam M.;Small, Scott A.;Fleisher, Adam
通讯作者：
Fleisher, Adam