Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery
Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery
复制标题
具有弱酸触发电荷反转的硫醚桥介孔有机二氧化硅纳米胶囊用于药物输送
DOI：
10.1016/j.micromeso.2020.110242
复制
发表时间：
2020-08
影响因子：
5.2
通讯作者：
Du Xin
中科院分区：
文献类型：
--
作者：
Zhou Mengyun;Xing Yi;Li Weike;Li Xiaoyu;Zhang Xueji;Du Xin
具有弱酸触发的表面电荷反转功能的药物递送纳米系统由于延长血液循环和增强细胞摄取而有望用于有效的化疗。然而，到目前为止，只有有限的报告。在本研究中，我们利用肿瘤微环境中的弱酸性，制备了一种具有正负电荷反转外层的杂化纳米胶囊。将带正电荷的短支链聚乙烯亚胺（PEI）和带负电荷的弱酸敏感性六氢邻苯二甲酸酐依次修饰在具有多个孔洞的硫醚桥连中空介孔二氧化硅纳米微球表面。PEI作为连接基团的修饰比氨丙基基团的修饰更有利于电荷反转。所构建的杂化纳米胶囊具有弱酸（pH 6.0）触发的电荷反转和药物释放行为，从而有效地抑制了A549癌细胞的生长。杂化纳米胶囊的表面功能化为硅基杂化纳米系统的开发提供了新的机会。
The drug delivery nanosystems with weak acid-triggered surface charge reversal function should be promising for efficient chemotherapy due to the prolonged blood circulation and enhanced the cellular uptake. However, there are only limited reports up to now. In this study, we fabricated a hybrid nanocapsule with a negative-to-positive charge-reversal outer layer triggered by the weak acidity in tumor microenvironment. The short branched polyethylenimine (PEI) with positive charge and weak acid-sensitive hexahydrophthalic anhydride with negative charge were successively modified on the surface of small uniform thioether-bridged hollow mesoporous silica nanospheres with multiple cavities. The modification of PEI as a linker was more favorable for charge reversal than that of aminopropyl group. The constructed hybrid nanocapsules exhibited weak acid (pH 6.0)-triggered charge reversal and drug release behaviors, thus effectively inhibiting the growth of A549 cancer cells. The surface functionalization of hybrid nanocapsules opens new opportunities for the development of silica-based hybrid nanosystems for promising drug delivery.
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DOI：
10.1002/chin.201227258
发表时间：
2012-07
期刊：
ChemInform
影响因子：
--
作者：
Zongxi Li;J. C. Barnes;Aleksandr Bosoy;J. Stoddart;J. Zink
通讯作者：
Zongxi Li;J. C. Barnes;Aleksandr Bosoy;J. Stoddart;J. Zink
影响因子：
9.5
作者：
P. Zhang;Tong Wu;J. Kong
通讯作者：
P. Zhang;Tong Wu;J. Kong
影响因子：
14
作者：
Xin Du;B. Shi;Youhong Tang;S. Dai;S. Qiao
通讯作者：
Xin Du;B. Shi;Youhong Tang;S. Dai;S. Qiao
DOI：
10.1039/c3tb20792g
发表时间：
2013-10
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
G. Luo;Weihai Chen;Yun Liu;Jing Zhang;Si-Xue Cheng;R. Zhuo;Xianzheng Zhang
通讯作者：
G. Luo;Weihai Chen;Yun Liu;Jing Zhang;Si-Xue Cheng;R. Zhuo;Xianzheng Zhang
影响因子：
10.8
作者：
Sauer, Anna M.;Schlossbauer, Axel;Braeuchle, Christoph
通讯作者：
Braeuchle, Christoph