Luminescent gold nanoparticles with efficient renal clearance.
Luminescent gold nanoparticles with efficient renal clearance.
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DOI：
10.1002/anie.201007321
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发表时间：
2011-03-28
影响因子：
16.6
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
Zhou, Chen;Long, Michael;Qin, Yanping;Sun, Xiankai;Zheng, Jie
开发具有高效肾脏清除功能的纳米材料对于它们在体内的生物医学应用是至关重要的。[1]理想的基于纳米材料的造影剂应该被有效地清除出体外，在器官中几乎没有积聚，并且对其他诊断试验的干扰最小。[1C，1E，2]虽然在制造具有高效肾脏清除的荧光量子点方面取得了重大进展，[2]贵金属纳米颗粒(NPs)在体内的应用，这是另一种在生物医学成像、药物输送、抗菌和光热治疗方面有前景的纳米药物，[3]由于系统给药后肾脏清除缓慢和网状内皮系统(RES)器官(如肝、脾)中非特异性高积聚，[3]仍然受到严重阻碍。[4]尽管流体动力学直径(HD)小于10 nm的NPs通常被认为对RES器官是隐形的，但它们仍然经常在肝脏中发现。[2A]例如，近50%的1.4 nm金NPs(AuNPs)存在于肝脏中，其中只有9%能在静脉注射(IV)后24小时内排泄到尿液中。开发能有效清除肾脏的金属纳米粒子，并对肾脏清除的关键因素有基本的了解是非常必要的。在这里，我们报道了~2 nm谷胱甘肽包裹的发光金纳米粒子(GS-AuNPs)的肾脏清除。我们发现，静脉注射后24小时，只有3.7±1.9%的颗粒聚集在肝脏，超过50%的颗粒存在于尿液中，这与已知的肾脏清除效率最高的量子点(Qds)相当。[2B]通过与半胱氨酸包裹的类似尺寸的AuNPs进行比较，[2b]我们发现谷胱甘肽在提高生理条件下AuNPs的稳定性方面优于半胱氨酸
Developing functional nanomaterials with efficient renal clearance is of fundamental importance to their in vivo biomedical applications.[1] Ideal nanomaterial based contrast agents should be effectively cleared out of the body, have little accumulation in organs and show minimum interference with other diagnostic tests.[1c, 1e, 2] While significant progress has been made toward the creation of fluorescent quantum dots with efficient renal clearance,[2] in vivo applications of noble metal nanoparticles (NPs), another promising nanomedicine in biomedical imaging, drug delivery, antibacterial and photothermal therapy,[3] are still severely hampered by their slow renal clearance and high nonspecific accumulations in the reticuloendothelial system (RES) organs (eg liver, spleen) after systematic administration.[4] Although NPs with hydrodynamic diameter (HD) smaller than 10 nm are generally considered being stealthy to the RES organs, they are still often found in the liver.[2a] For example, nearly~ 50% of 1.4 nm gold NPs (AuNPs) were found in the liver and only~ 9% of them can be excreted into urine in 24 hours after intravenous (IV) injection.[4b] Therefore, developing metal NPs with efficient renal clearance and fundamental understanding of key factors in renal clearance are highly desirable.Herein, we report renal clearance of~ 2 nm glutathione coated luminescent gold NPs (GS-AuNPs). We found that only 3.7±1.9% of the particles were accumulated in the liver and more than 50% of the particles were found in urine in 24 hours after IV injection, which is comparable to the known quantum dots (QDs) with the best renal clearance efficiency.[2b] By comparing with similar sized AuNPs coated with cysteine, a ligand that can significantly enhance renal clearance of quantum dots in vivo,[2b] we found that glutathione has advantages over cysteine in enhancing the stability of AuNPs under physiological
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影响因子：
56.9
作者：
NEURATH, H
通讯作者：
NEURATH, H
DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
16.6
作者：
Bakr, Osman M.;Amendola, Vincenzo;Stellacci, Francesco
通讯作者：
Stellacci, Francesco
体内模型系统中TNF-α涂层金纳米颗粒的生物分布。
DOI：
10.2217/nnm.09.21
发表时间：
2009-06
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Goel R;Shah N;Visaria R;Paciotti GF;Bischof JC
通讯作者：
Bischof JC
影响因子：
3.5
作者：
Retnakumari, Archana;Setua, Sonali;Koyakutty, Manzoor
通讯作者：
Koyakutty, Manzoor