A noncanonical auxin-sensing mechanism is required for organ morphogenesis in Arabidopsis.
A noncanonical auxin-sensing mechanism is required for organ morphogenesis in Arabidopsis.
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拟南芥中器官形态发生需要一种非规范的生长素感应机制。
DOI：
10.1101/gad.285361.116
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发表时间：
2016-10-15
影响因子：
10.5
通讯作者：
Østergaard L
中科院分区：
文献类型：
--
作者：
Simonini S;Deb J;Moubayidin L;Stephenson P;Valluru M;Freire-Rios A;Sorefan K;Weijers D;Friml J;Østergaard L
Simonini等人提出了另一种生长素感应机制，其中生长素反应因子ARF 3/ETTIN通过与过程特异性转录因子的相互作用来控制基因表达。多细胞生物体中的组织图案化是基因表达的精确时空调控与激素动力学变化的产物。在植物中，生长素激素在植物生命周期的每个阶段调节生长和发育。生长素信号通过生长素分子与TIR 1/AFB F-box泛素连接酶结合而发生，从而允许与Aux/IAA转录阻遏蛋白相互作用。这些随后被泛素化并通过26 S蛋白酶体降解，导致生长素反应因子（ARF）的去抑制。生长素是如何通过一个单一的信号模块引发如此多样化的发育反应的，这一点尚未得到解决。在这里，我们提出了一种替代的生长素传感机制，其中ARF ARF 3/ETTIN通过与过程特异性转录因子的相互作用来控制基因表达。这种非经典的植物生长感应机制表现出对天然生长素吲哚3-乙酸（IAA）的强烈偏好，并且对于协调不同发育环境中的生长和图案化非常重要，如雌蕊形态发生，侧根出现，胚珠发育和初级分支形成。破坏这种IAA传感能力诱导形态畸变与植物健身的后果。因此，我们的研究结果介绍了一种新的转录因子为基础的机制激素的感知植物。
Simonini et al. present an alternative auxin-sensing mechanism in which the auxin response factor ARF3/ETTIN controls gene expression through interactions with process-specific transcription factors. Tissue patterning in multicellular organisms is the output of precise spatio–temporal regulation of gene expression coupled with changes in hormone dynamics. In plants, the hormone auxin regulates growth and development at every stage of a plant's life cycle. Auxin signaling occurs through binding of the auxin molecule to a TIR1/AFB F-box ubiquitin ligase, allowing interaction with Aux/IAA transcriptional repressor proteins. These are subsequently ubiquitinated and degraded via the 26S proteasome, leading to derepression of auxin response factors (ARFs). How auxin is able to elicit such a diverse range of developmental responses through a single signaling module has not yet been resolved. Here we present an alternative auxin-sensing mechanism in which the ARF ARF3/ETTIN controls gene expression through interactions with process-specific transcription factors. This noncanonical hormone-sensing mechanism exhibits strong preference for the naturally occurring auxin indole 3-acetic acid (IAA) and is important for coordinating growth and patterning in diverse developmental contexts such as gynoecium morphogenesis, lateral root emergence, ovule development, and primary branch formation. Disrupting this IAA-sensing ability induces morphological aberrations with consequences for plant fitness. Therefore, our findings introduce a novel transcription factor-based mechanism of hormone perception in plants.
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影响因子：
3.7
作者：
Belda-Palazón B;Ruiz L;Martí E;Tárraga S;Tiburcio AF;Culiáñez F;Farràs R;Carrasco P;Ferrando A
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作者：
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作者：
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通讯作者：
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影响因子：
4.6
作者：
Gremski, Kristina;Ditta, Gary;Yanofsky, Martin F.
通讯作者：
Yanofsky, Martin F.