Endogenous oxytocin levels are associated with the perception of emotion in dynamic body expressions in schizophrenia.

Endogenous oxytocin levels are associated with the perception of emotion in dynamic body expressions in schizophrenia.
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DOI:
10.1016/j.schres.2015.01.022
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发表时间:
2015-03
影响因子:
4.5
通讯作者:
Buchanan, Robert W.
Buchanan, Robert W.
中科院分区:
医学2区
文献类型:
--
作者:
Strauss, Gregory P.;Keller, William R.;Koenig, James I.;Sullivan, Sara K.;Gold, James M.;Buchanan, Robert W.

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内源性催产素水平较低与精神分裂症患者的社会认知受损有关,特别是面部情感识别。关于催产素和其他形式的情绪知觉之间的关系,人们知之甚少。在目前的研究中,41名精神分裂症患者(SZ)和22名人口统计学上匹配的健康对照(CN)完成了强制选择情感身体表达分类任务。刺激包括男性和女性演员描绘四种不同情绪的动态视频:快乐、悲伤、愤怒和中性。用放射免疫法测定血浆催产素水平。结果表明,SZ组血浆催产素浓度显著高于CN组。SZ在识别快乐和悲伤的表情方面也不太准确;然而,在愤怒或中性刺激方面没有组别差异。女性CN比男性CN更准确,而男性SZ比女性SZ更准确。更高的内源性催产素水平与SZ和CN中更好的总体识别相关;这种关联是SZ女性特有的。研究结果表明,性别在识别深圳人身体姿势中的情绪表达中起着重要作用,内源性催产素的个体差异预测了情绪感知的准确性。
Lower endogenous oxytocin levels have been associated with impaired social cognition in schizophrenia, particularly facial affect identification. Little is known about the relationship between oxytocin and other forms of emotion perception. In the current study, 41 individuals with schizophrenia (SZ) and 22 demographically matched healthy controls (CN) completed a forced-choice affective body expression classification task. Stimuli included dynamic videos of male and female actors portraying 4 discrete emotions: happiness, sadness, anger, and neutral. Plasma oxytocin levels were determined via radioimmunoassay. Results indicated that SZ had significantly higher plasma oxytocin concentrations than CN. SZ were also less accurate at identifying expressions of happiness and sadness; however, there were no group differences for anger or neutral stimuli. A group x sex interaction was also present, such that female CN were more accurate than male CN, whereas male SZ were more accurate than female SZ. Higher endogenous oxytocin levels were associated with better total recognition in both SZ and CN; this association was specific to females in SZ. Findings indicate that sex plays an important role in identifying emotional expressions in body gestures in SZ, and that individual differences in endogenous oxytocin predict emotion perception accuracy.
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