Imaging peripheral lymphatic dysfunction in chronic conditions.

Imaging peripheral lymphatic dysfunction in chronic conditions.
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DOI:
10.3389/fphys.2023.1132097
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发表时间:
2023
影响因子:
4
通讯作者:
--
中科院分区:
医学2区
文献类型:
--
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这些药物在慢性疾病/病症中发挥着重要作用,这些疾病/病症构成了全球大部分医疗保健。然而,使用常用的临床成像方式常规成像和诊断淋巴功能障碍的能力一直缺乏,因此,有效治疗策略的开发受到影响。近二十年前,研究性近红外荧光淋巴成像和ICG淋巴造影被开发为临床评估、量化和治疗癌症相关和原发性水肿、慢性静脉疾病以及最近的自身免疫和神经退行性疾病中的淋巴功能障碍的常规诊断。在这篇综述中,我们提供了一个概述这些非侵入性技术教我们淋巴(dys)的功能和解剖在人类研究和人类疾病的必然动物研究。我们通过评论淋巴科学中仍有待成像促进的新的有影响力的临床前沿来进行总结。
The lymphatics play important roles in chronic diseases/conditions that comprise the bulk of healthcare worldwide. Yet the ability to routinely image and diagnose lymphatic dysfunction, using commonly available clinical imaging modalities, has been lacking and as a result, the development of effective treatment strategies suffers. Nearly two decades ago, investigational near-infrared fluorescence lymphatic imaging and ICG lymphography were developed as routine diagnostic for clinically evaluating, quantifying, and treating lymphatic dysfunction in cancer-related and primary lymphedema, chronic venous disease, and more recently, autoimmune and neurodegenerative disorders. In this review, we provide an overview of what these non-invasive technologies have taught us about lymphatic (dys) function and anatomy in human studies and in corollary animal studies of human disease. We summarize by commenting on new impactful clinical frontiers in lymphatic science that remain to be facilitated by imaging.
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