Microglia and synapse interactions: fine tuning neural circuits and candidate molecules.
Microglia and synapse interactions: fine tuning neural circuits and candidate molecules.
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DOI：
10.3389/fncel.2013.00070
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发表时间：
2013
影响因子：
5.3
通讯作者：
Nabekura J
中科院分区：
文献类型：
--
作者：
Miyamoto A;Wake H;Moorhouse AJ;Nabekura J
大脑的功能主要取决于构成神经回路的潜在成分之间的相互作用。这包括突触前和突触后神经元元件的协调活动，但也包括非神经元元件，如胶质细胞。小胶质细胞是中枢神经系统（CNS）中的胶质细胞，在神经元免疫功能，对感染和脑损伤作出反应以及影响神经退行性疾病的进展中具有众所周知的作用。然而，小胶质细胞也是健康大脑的调查员，它们不断地扩展和收缩它们的过程，并与神经回路的突触前和突触后元件接触，这一过程显然消耗了相当大的能量。在发育过程中突触的修剪和对损伤的反应也有记录，我们认为这种对成年健康大脑的脑实质的广泛监测导致了类似的神经回路“微调”。一个合理的延伸是，小胶质细胞的这种内平衡作用的功能障碍可能是神经元疾病的主要原因。事实上，包括认知、人格和信息处理在内的神经元功能都受到免疫状态的影响。在这篇综述中，我们主要关注小胶质细胞和突触之间的相互作用，介导这种接触的可能的细胞和分子机制，以及这些相互作用在神经回路的微调中可能具有的意义，而神经回路对大脑的生理功能是如此重要。
Brain function depends critically on the interactions among the underlying components that comprise neural circuits. This includes coordinated activity in pre-synaptic and postsynaptic neuronal elements, but also in the non-neuronal elements such as glial cells. Microglia are glial cells in the central nervous system (CNS) that have well-known roles in neuronal immune function, responding to infections and brain injury and influencing the progress of neurodegenerative disorders. However, microglia are also surveyors of the healthy brain, continuously extending and retracting their processes and making contacts with pre- and postsynaptic elements of neural circuits, a process that clearly consumes considerable energy. Pruning of synapses during development and in response to injury has also been documented, and we propose that this extensive surveillance of the brain parenchyma in adult healthy brain results in similar “fine-tuning” of neural circuits. A reasonable extension is that a dysfunction of such a homeostatic role of microglia could be a primary cause of neuronal disease. Indeed, neuronal functions including cognition, personality, and information processing are affected by immune status. In this review we focus on the interactions between microglia and synapses, the possible cellular and molecular mechanisms that mediate such contacts, and the possible implications these interactions may have in the fine tuning of neural circuits that is so important for physiological brain function.
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影响因子：
3.3
作者：
Glausier, J. R.;Lewis, D. A.
通讯作者：
Lewis, D. A.
影响因子：
--
作者：
Cullheim, Staffan;Thams, Sebastian
通讯作者：
Thams, Sebastian
影响因子：
56.9
作者：
Huh, GS;Boulanger, LM;Shatz, CJ
通讯作者：
Shatz, CJ
DOI：
10.1007/bf00325030
发表时间：
1968-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
BLINZING.K;KREUTZBE.G
通讯作者：
KREUTZBE.G
小胶质细胞形态和动态行为受离子型谷氨酸能和GABA能神经传递的调节。
影响因子：
3.7
作者：
Fontainhas AM;Wang M;Liang KJ;Chen S;Mettu P;Damani M;Fariss RN;Li W;Wong WT
通讯作者：
Wong WT