Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction.
Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction.
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CD56（NKH-1/LEU-19抗原）作为天然杀手靶细胞相互作用的粘附分子的参与。
DOI：
10.1084/jem.170.5.1757
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发表时间：
1989-11-01
影响因子：
15.3
通讯作者：
OKUMURA, K
中科院分区：
文献类型：
--
作者：
NITTA, T;YAGITA, H;SATO, K;OKUMURA, K
The CD56 differentiation antigen, recognized by anti-Leu-19 and NKH-1 mAbs, is a 200-220-kD glycoprotein that is expressed predominantly on human NK cells and a minor subset of T lymphocytes mediating MHC- unrestricted cytotoxicity. The recent finding that CD56 is an isoform of the neural cell adhesion molecule (N-CAM) prompted us to examine the adhesive function of CD56 in the NK-target cell interaction. Synergistic inhibitory effects of anti-CD56 mAbs with anti-LFA-1 and/or anti-LFA-3 mAbs were demonstrated on NK cell-mediated cytotoxicity and on NK cell binding to target cells only when the target cells also express CD56. These findings indicate that CD56 on NK cells can serve as the third pathway of cell adhesion other than those mediated by the CD2/LFA-3 and LFA-1/ICAM-1 interactions, and is involved in NK cell cytotoxicity when interacting with the cells bearing N-CAM.
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DOI：
10.1084/jem.169.6.2233
发表时间：
1989-06-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lanier LL;Testi R;Bindl J;Phillips JH
通讯作者：
Phillips JH
影响因子：
64.8
作者：
STAUNTON, DE;DUSTIN, ML;SPRINGER, TA
通讯作者：
SPRINGER, TA
DOI：
10.1084/jem.170.4.1445
发表时间：
1989-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Yagita H;Nakata M;Azuma A;Nitta T;Takeshita T;Sugamura K;Okumura K
通讯作者：
Okumura K
DOI：
10.1073/pnas.79.23.7489
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
SANCHEZMADRID, F;KRENSKY, AM;SPRINGER, TA
通讯作者：
SPRINGER, TA
影响因子：
15.9
作者：
HERCEND, T;GRIFFIN, JD;RITZ, J
通讯作者：
RITZ, J