Activation of peripheral blood T cells via the p75 interleukin 2 receptor.
Activation of peripheral blood T cells via the p75 interleukin 2 receptor.
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DOI：
10.1084/jem.170.4.1445
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发表时间：
1989-10-01
期刊：
影响因子：
--
通讯作者：
Okumura K
中科院分区：
文献类型：
--
作者：
Yagita H;Nakata M;Azuma A;Nitta T;Takeshita T;Sugamura K;Okumura K
By using mAb and flow cytometry, a constitutive expression of the p75 IL-2R was revealed in human peripheral blood CD8+ T cells and TCR delta- 1+ T cells as well as in CD16+ NK cells. Anti-p75 IL-2R mAb almost completely inhibited the induction of cytolytic activity in these T cells by brief exposure to IL-2, as estimated by anti-TCR/CD3 mAb- targeted cytotoxicity. While anti-p55 IL-2R mAb alone inhibited the response only modestly, maximal inhibition was achieved by combining both anti-p55 and anti-p75 IL-2R mAbs. These results indicate that the p75 IL-2R constitutively expressed on peripheral blood CD8+ T cells and TCR delta-1+ T cells is predominantly responsible for the direct activation of these cells by IL-2.
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影响因子：
15.3
作者：
WEINBERGER, JZ;GERMAIN, RN;DORF, ME
通讯作者：
DORF, ME
影响因子：
15.3
作者：
PHILLIPS, JH;TAKESHITA, T;SUGAMURA, K;LANIER, LL
通讯作者：
LANIER, LL
解剖淋巴细胞激活的杀手现象。外周血天然杀伤细胞和T淋巴细胞对胞溶性的相对贡献。
DOI：
10.1084/jem.164.3.814
发表时间：
1986-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Phillips JH;Lanier LL
通讯作者：
Lanier LL
影响因子：
56.9
作者：
BAND, H;HOCHSTENBACH, F;BRENNER, MB
通讯作者：
BRENNER, MB
DOI：
10.1084/jem.158.4.1356
发表时间：
1983-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Grimm EA;Robb RJ;Roth JA;Neckers LM;Lachman LB;Wilson DJ;Rosenberg SA
通讯作者：
Rosenberg SA