Effects of damage to auditory cortex on the discrimination of speech sounds by rats.
Effects of damage to auditory cortex on the discrimination of speech sounds by rats.
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DOI：
10.1016/j.physbeh.2010.05.009
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发表时间：
2010-09-01
影响因子：
2.9
通讯作者：
Kilgard, Michael P.
中科院分区：
文献类型：
--
作者：
Floody, Owen R.;Ouda, Ladislav;Porter, Benjamin A.;Kilgard, Michael P.
噪声诱发惊吓反应的强度可以通过在噪声之前立即出现中性刺激（“脉冲前抑制”或PPI）来降低。我们用一种形式的PPI研究了听觉皮层损伤对大鼠语音识别的影响。受试者接受对照手术或用血管收缩剂内皮素-1治疗听觉皮层。这种治疗造成的损伤集中在初级听觉皮层（A1）。在损伤前后，对受试者进行了5项任务测试，其中大多数任务呈现一对人类语音（辅音-元音音节），因此辨别能力在PPI程度上是明显的。组间比较未发现任何一致的病变效果。与此同时，通过多元回归对个体表现差异的分析表明，辨别语音所需的一些时间处理集中在右脑A1的腹侧。这些结果也证实，PPI可以适用于研究涉及言语和其他复杂声音处理的大脑机制。
The intensity of a noise-induced startle response can be reduced by the presentation of an otherwise neutral stimulus immediately before the noise (“prepulse inhibition” or PPI). We used a form of PPI to study the effects of damage to auditory cortex on the discrimination of speech sounds by rats. Subjects underwent control surgery or treatment of the auditory cortex with the vasoconstrictor endothelin-1. This treatment caused damage concentrated in primary auditory cortex (A1). Both before and after lesions, subjects were tested on 5 tasks, most presenting a pair of human speech sounds (consonant-vowel syllables) so that the capacity for discrimination would be evident in the extent of PPI. Group comparisons failed to reveal any consistent lesion effect. At the same time, the analysis of individual differences in performance by multiple regression suggests that some of the temporal processing required to discriminate speech sounds is concentrated anteroventrally in the right A1. These results also confirm that PPI can be adapted to studies of the brain mechanisms involved in the processing of speech and other complex sounds.
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影响因子：
1.9
作者：
ISON, JR;OCONNOR, K;BOCIRNEA, A
通讯作者：
BOCIRNEA, A
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN
影响因子：
56.9
作者：
Kilgard, MP;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
2.5
作者：
Adkins, DL;Jones, TA
通讯作者：
Jones, TA
影响因子：
--
作者：
BARU A V;SHMIGIDINA G N
通讯作者：
SHMIGIDINA G N