Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease.
Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease.
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DOI：
10.1016/j.jalz.2012.05.2186
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Mielke MM
中科院分区：
文献类型：
--
作者：
Nowrangi MA;Lyketsos CG;Leoutsakos JM;Oishi K;Albert M;Mori S;Mielke MM
弥散张量成像(DTI)是一种检测正常对照组(NC)和轻度认知障碍(MCI)或阿尔茨海默病(AD)患者脑白质束横断面差异的有效方法。确定其纵向效用的研究并不多。75名参与者(25名NC，25名遗忘型MCI和25名AD)在基线、3、6和12个月时进行了3Tesla MRI扫描和临床评估。对取自4个感兴趣区(ROI)的8个先验区域在每个时间点和纵向上分析分数各向异性(FA)和平均弥散率(MD)。在横断面上，AD组穹隆和穹隆的MD值高于MCI或NC，而FA值低于NC(P<；.01)。12个月后MD组的变化比FA组更明显：MCI组和AD组的下扣带、前扣带和穹隆的MD均增加(P<；.01)。在超过12个月的每个时间点，正常对照组和AD组在FA和MD组之间都有稳定的、横截面的、特定于区域的差异。从纵向来看，MD比FA更能反映变化。MCI组穹窿MD显著增加，提示这是病情进展的早期指标。
Diffusion tensor imaging (DTI) is a promising method for identifying significant cross-sectional differences of white-matter tracts in normal controls (NC) and those with mild cognitive impairment (MCI) or Alzheimer’s disease (AD). There have not been many studies establishing its longitudinal utility. Seventy-five participants (25 NC, 25 amnestic MCI, and 25 AD) had 3-Tesla MRI scans and clinical evaluations at baseline and 3, 6, and 12 months. Fractional anisotropy (FA) and mean diffusivity (MD) were analyzed at each time-point and longitudinally in eight a priori–selected areas taken from four regions of interest (ROIs). Cross-sectionally, MD values were higher, and FA values lower in the fornix and splenium of the AD group compared with either MCI or NC (P < .01).Within-group change was more evident in MD than in FA over 12 months: MD increased in the inferior, anterior cingulum, and fornix in both the MCI and AD groups (P < .01). There were stable, cross-sectional, region-specific differences between the NC and AD groups in both FA and MD at each time-point over 12 months. Longitudinally, MD was a better indicator of change than FA. Significant increases of fornix MD in the MCI group suggest this is an early indicator of progression.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
9.9
作者：
Kantarci, K;Petersen, RC;Jack, CR
通讯作者：
Jack, CR
影响因子：
2.4
作者：
Englund, E
通讯作者：
Englund, E
影响因子：
4.2
作者：
Fellgiebel, A;Müller, MJ;Stoeter, P
通讯作者：
Stoeter, P
影响因子：
2.4
作者：
Bronge, L;Bogdanovic, N;Wahlund, LO
通讯作者：
Wahlund, LO