Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans.
Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans.
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DOI：
10.1007/s00213-012-2924-5
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发表时间：
2013-04
影响因子：
3.4
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Ballard, Michael E.;Gallo, David A.;de Wit, Harriet
众所周知，许多成瘾药物会对学习和记忆产生影响，这些影响可能会刺激未来的药物使用。具体来说，成瘾药物可能会以对某些使用者有吸引力的方式影响情绪事件和经历的记忆。然而，很少有研究调查成瘾药物对人类情绪记忆的影响。这项研究考察了记忆增强药物右旋苯丙胺 (AMP) 和记忆损害药物 Δ9-四氢大麻酚 (THC) 对健康志愿者情绪记忆的影响。参与者完成了三个实验，在观看积极（愉快）、中性和消极（不愉快）场景的图片之前，他们接受了含有安慰剂和两剂 AMP（10 和 20 毫克；N=25）或 THC（7.5 和 15 毫克；N=25）的胶囊。两天后，在没有药物的条件下，对这些图片的记忆进行了评估。与安慰剂相比，AMP 改善了对情感图片的记忆，而 THC 则损害了记忆，但这两种药物都没有显着影响非情感图片的记忆。这两种药物都没有观察到积极的记忆偏差，并且没有迹象表明药物的记忆效应与其主观或生理效应直接相关。这项研究提供了第一个明确的证据，证明兴奋剂药物可以优先增强人类对情绪事件的记忆，而大麻素可以优先损害人类对情绪事件的记忆。尽管成瘾药物似乎不会对记忆产生积极影响，但这些药物对情绪记忆的影响仍然有可能影响某些人的药物使用。
Many addictive drugs are known to have effects on learning and memory, and these effects could motivate future drug use. Specifically, addictive drugs may affect memory of emotional events and experiences in ways that are attractive to some users. However, few studies have investigated the effects of addictive drugs on emotional memory in humans. This study examined the effects of the memory-enhancing drug dextroamphetamine (AMP) and the memory-impairing drug Δ9-tetrahydrocannabinol (THC) on emotional memory in healthy volunteers. Participants completed three experimental sessions across which they received capsules containing placebo and two doses of either AMP (10 and 20 mg; N=25) or THC (7.5 and 15 mg; N=25) before viewing pictures of positive (pleasant), neutral, and negative (unpleasant) scenes. Memory for the pictures was assessed two days later, under drug-free conditions. Relative to placebo, memory for emotional pictures was improved by AMP and impaired by THC, but neither drug significantly affected memory for unemotional pictures. Positive memory biases were not observed with either drug, and there was no indication that the drugs’ memory effects were directly related to their subjective or physiological effects alone. This study provides the first clear evidence that stimulant drugs can preferentially strengthen, and cannabinoids can preferentially impair, memory for emotional events in humans. Although addictive drugs do not appear to positively bias memory, the possibility remains that these drugs’ effects on emotional memory could influence drug use among certain individuals.
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影响因子：
3.4
作者：
Ballard, Michael E.;Gallo, David A.;de Wit, Harriet
通讯作者：
de Wit, Harriet
影响因子：
2.4
作者：
Cahill, L;McGaugh, JL
通讯作者：
McGaugh, JL
影响因子：
3.4
作者：
Curran, HV;Brignell, C;Henry, J
通讯作者：
Henry, J
DOI：
10.2201/nonlin.003.01.002
发表时间：
2005-01-01
期刊：
Nonlinearity in Biology Toxicology and Medicine
影响因子：
--
作者：
Baldi, Elisabetta;Bucherelli, Corrado
通讯作者：
Bucherelli, Corrado
影响因子：
4.1
作者：
Del-Ben, Cristina M.;Ferreira, Cesar A. Q.;Graeff, Frederico G.
通讯作者：
Graeff, Frederico G.