Psychoactive drugs and false memory: comparison of dextroamphetamine and δ-9-tetrahydrocannabinol on false recognition.
Psychoactive drugs and false memory: comparison of dextroamphetamine and δ-9-tetrahydrocannabinol on false recognition.
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DOI：
10.1007/s00213-011-2374-5
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发表时间：
2012-01
影响因子：
3.4
通讯作者：
de Wit, Harriet
中科院分区：
文献类型：
--
作者：
Ballard, Michael E.;Gallo, David A.;de Wit, Harriet
关键词：
已知有几种精神活性药物会影响情景记忆。然而，这些药物对错误记忆或错误记住未研究信息的倾向的影响仍然知之甚少。在这里，我们使用 Deese/Roediger–McDermott (DRM) 错觉检查了两种常用的精神活性药物对错误记忆的影响，其中一种具有增强记忆的特性（右旋安非他明；AMP），另一种具有记忆损害的特性（Δ9-四氢大麻酚；THC）。进行了两项平行研究，其中健康志愿者在受试者内、随机、双盲设计中接受 AMP（0、10 和 20 毫克）或 THC（0、7.5 和 15 毫克）。参与者在药物的影响下研究了 DRM 单词列表，并在 2 天后在清醒条件下测试了他们对所研究单词的识别记忆。正如预期的那样，相对于安慰剂，AMP 增加了所学单词的记忆，而 THC 减少了所学单词的记忆。虽然与安慰剂相比，这两种药物都不会显着影响错误记忆，但与 THC 相比，AMP 会增加错误记忆。在参与者中，两种药物对真实记忆的影响与其对错误记忆的影响呈正相关。我们的结果表明，AMP 和 THC 对真实记忆有相反的影响，这些影响似乎与对错误记忆的类似影响相对应，尽管更微妙。这些发现与之前使用 DRM 错觉的研究一致，并提供了进一步的证据，证明精神活性药物可以影响编码过程，最终导致错误记忆的产生。
Several psychoactive drugs are known to influence episodic memory. However, these drugs’ effects on false memory, or the tendency to incorrectly remember nonstudied information, remain poorly understood. Here, we examined the effects of two commonly used psychoactive drugs, one with memory-enhancing properties (dextroamphetamine; AMP), and another with memory-impairing properties (Δ9-tetrahydrocannabinol; THC), on false memory using the Deese/Roediger–McDermott (DRM) illusion. Two parallel studies were conducted in which healthy volunteers received either AMP (0, 10, and 20 mg) or THC (0, 7.5, and 15 mg) in within-subjects, randomized, double-blind designs. Participants studied DRM word lists under the influence of the drugs, and their recognition memory for the studied words was tested 2 days later, under sober conditions. As expected, AMP increased memory of studied words relative to placebo, and THC reduced memory of studied words. Although neither drug significantly affected false memory relative to placebo, AMP increased false memory relative to THC. Across participants, both drugs’ effects on true memory were positively correlated with their effects on false memory. Our results indicate that AMP and THC have opposing effects on true memory, and these effects appear to correspond to similar, albeit more subtle, effects on false memory. These findings are consistent with previous research using the DRM illusion and provide further evidence that psychoactive drugs can affect the encoding processes that ultimately result in the creation of false memories.
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影响因子：
3.4
作者：
Huron, C;Servais, C;Danion, JM
通讯作者：
Danion, JM
影响因子：
3.4
作者：
Curran, HV;Brignell, C;Henry, J
通讯作者：
Henry, J
影响因子：
2.4
作者：
Thapar, A;McDermot, KB
通讯作者：
McDermot, KB
影响因子：
4.2
作者：
Wachtel, SR;de Wit, H
通讯作者：
de Wit, H
影响因子：
6.9
作者：
FOLSTEIN, MF;LURIA, R
通讯作者：
LURIA, R