Implications of leg length for metabolic health and fitness.
Implications of leg length for metabolic health and fitness.
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DOI：
10.1093/emph/eoac023
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发表时间：
2022
影响因子：
3.7
通讯作者：
Wells, Jonathan C. K.
中科院分区：
文献类型：
--
作者：
Shirley, Meghan K.;Arthurs, Owen J.;Seunarine, Kiran K.;Cole, Tim J.;Eaton, Simon;Williams, Jane E.;Clark, Chris A.;Wells, Jonathan C. K.
Several studies have linked longer legs with favorable adult metabolic health outcomes and greater offspring birth weight. A recent Mendelian randomization study suggested a causal link between height and cardiometabolic risk; however, the underlying reasons remain poorly understood. Using a cross-sectional design, we tested in a convenience sample of 70 healthy young women whether birth weight and tibia length as markers of early-life conditions associated more strongly with metabolically beneficial traits like organ size and skeletal muscle mass (SMM) than a statistically derived height-residual variable indexing later, more canalized growth. Consistent with the ‘developmental origins of health and disease’ hypothesis, we found relatively strong associations of tibia length—but not birth weight—with adult organ size, brain size, SMM and resting energy expenditure measured by magnetic resonance imaging (MRI), dual-energy X-ray absorptiometry and indirect calorimetry, respectively. Building on prior work, these results suggest that leg length is a sensitive marker of traits directly impacting metabolic and reproductive health. Alongside findings in the same sample relating tibia length and height-residual to MRI-measured pelvic dimensions, we suggest there may exist a degree of coordination in the development of long bone, lean mass and pelvic traits, possibly centered on early, pre-pubertal growth periods. Such phenotypic coordination has important implications for fitness, serving to benefit both adult health and the health of offspring in subsequent generations.
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影响因子：
6
作者：
FULLER, NJ;JEBB, SA;ELIA, M
通讯作者：
ELIA, M
影响因子：
2.9
作者：
Chung, Green C.;Kuzawa, Christopher W.
通讯作者：
Kuzawa, Christopher W.
DOI：
10.1016/j.jpeds.2016.05.013
发表时间：
2016-08
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Cusick SE;Georgieff MK
通讯作者：
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影响因子：
5.2
作者：
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通讯作者：
FALL, CHD
影响因子：
168.9
作者：
Gunnell, D;Smith, GD;Frankel, S
通讯作者：
Frankel, S