Trunk Neural Crest Migratory Position and Asymmetric Division Predict Terminal Differentiation.
Trunk Neural Crest Migratory Position and Asymmetric Division Predict Terminal Differentiation.
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DOI：
10.3389/fcell.2022.887393
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
胚胎发生过程中复杂结构的产生需要来自遥远起源的细胞的受控迁移和分化。这些过程如何协调并相互影响以形成功能结构尚不完全清楚。神经嵴细胞广泛迁移，产生多种细胞类型。在躯干中，神经嵴细胞集体迁移，形成由具有不同迁移特性的细胞组成的链：位于组前面的一个领导细胞指导迁移，而追随者则跟踪形成链主体的领导者。在此，我们分析了躯干神经嵴迁移特性与终末分化之间的关系。我们发现躯干神经嵴的迁移和命运分配是一致的。启动运动的领导细胞产生最远端的衍生。有趣的是，领导者的不对称划分将移民的身份和命运分开。远端子细胞保留领导者身份并克隆形成交感神经节。近端兄弟姐妹作为跟随者迁移并产生雪旺细胞。交感神经元转录因子 phox2bb 在迁移早期阶段的前导序列中强烈表达，表明规范和迁移同时且协调地发生。追随者对称分配，他们的命运与他们在链条中的位置相关。
The generation of complex structures during embryogenesis requires the controlled migration and differentiation of cells from distant origins. How these processes are coordinated and impact each other to form functional structures is not fully understood. Neural crest cells migrate extensively giving rise to many cell types. In the trunk, neural crest cells migrate collectively forming chains comprised of cells with distinct migratory identities: one leader cell at the front of the group directs migration, while followers track the leader forming the body of the chain. Herein we analysed the relationship between trunk neural crest migratory identity and terminal differentiation. We found that trunk neural crest migration and fate allocation is coherent. Leader cells that initiate movement give rise to the most distal derivativities. Interestingly, the asymmetric division of leaders separates migratory identity and fate. The distal daughter cell retains the leader identity and clonally forms the Sympathetic Ganglia. The proximal sibling migrates as a follower and gives rise to Schwann cells. The sympathetic neuron transcription factor phox2bb is strongly expressed by leaders from early stages of migration, suggesting that specification and migration occur concomitantly and in coordination. Followers divide symmetrically and their fate correlates with their position in the chain.
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影响因子：
7.7
作者：
Isern J;García-García A;Martín AM;Arranz L;Martín-Pérez D;Torroja C;Sánchez-Cabo F;Méndez-Ferrer S
通讯作者：
Méndez-Ferrer S
Notch控制了细胞周期，以定义集体细胞迁移期间的领导者与追随者身份。
影响因子：
7.7
作者：
Alhashem, Zain;Feldner-Busztin, Dylan;Revell, Christopher;Portillo, Macarena Alvarez-Garcillan;Camargo-Sosa, Karen;Richardson, Joanna;Rocha, Manuel;Gauert, Anton;Corbeaux, Tatianna;Milanetto, Martina;Argenton, Francesco;Tiso, Natascia;Kelsh, Robert N.;Prince, Victoria E.;Bentley, Katie;Linker, Claudia
通讯作者：
Linker, Claudia
影响因子：
64.5
作者：
Adameyko, Igor;Lallemend, Francois;Ernfors, Patrik
通讯作者：
Ernfors, Patrik
影响因子：
2.6
作者：
ERNSBERGER, U;PATZKE, H;ROHRER, H
通讯作者：
ROHRER, H
影响因子：
4.6
作者：
El-Nachef, Wael Noor;Bronner, Marianne E.
通讯作者：
Bronner, Marianne E.