Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates.
Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates.
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失语症的动作理解：语言和非语言缺陷及其病变相关性。
DOI：
10.1016/j.neuropsychologia.2004.04.016
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发表时间：
2004
期刊：
影响因子：
2.6
通讯作者：
Bates,Elizabeth
中科院分区：
文献类型：
--
作者：
Saygin,AysePinar;Wilson,StephenM;Dronkers,NinaF;Bates,Elizabeth
我们测试了失语症患者对动作的理解，以检查语言和非语言领域的处理缺陷及其病变相关性。29名左半球受伤的患者和18名年龄匹配的对照组受试者将图片动作（缺少对象）或其语言等价物（缺少对象的打印句子）与两张视觉呈现的对象图片之一相匹配。失语症患者不仅在语言领域表现不佳，而且在非语言领域也表现不佳。一个子集的患者，主要包括严重和非流利的失语症，表现出更大的赤字在语言领域相比，非语言领域和整个患者组，赤字在语言和非语言领域并不紧密相关。在哑剧解释的表现不佳与下额叶，前运动和运动皮层，体感皮层的一部分，和尾状核的病变，而穷人的阅读理解的行动与周围的病变前上级颞叶，前额叶和前部分的下顶叶。病变大小与缺损程度无关。哑剧解释缺陷的病变结果表明，在人类模拟的“镜像神经元系统”的额叶组件的病变与非语言动作理解的缺陷。对于阅读理解缺陷，损伤相关的是已知参与语言任务（包括句子处理和语音清晰度）的大脑区域;顶叶损伤部位也可能对应于人类镜像神经元系统的子部分。这些结果表明，对语言和动作产生重要的大脑区域也在他们的理解中被招募。在电生理学和神经影像学研究中也有类似的发现。我们的研究结果现在也为行动处理的大脑组织的体现观点提供了神经心理学支持。
We tested aphasic patients’ comprehension of actions to examine processing deficits in the linguistic and non-linguistic domains and their lesion correlates. Twenty-nine left-hemisphere injured patients and 18 age-matched control subjects matched pictured actions (with the objects missing) or their linguistic equivalents (printed sentences with the object missing) to one of two visually-presented pictures of objects. Aphasic patients performed poorly not only in the linguistic domain but also in the non-linguistic domain. A subset of the patients, largely consisting of severe and non-fluent aphasics, showed a greater deficit in the linguistic domain compared with the non-linguistic domain and across the patient group, deficits in the linguistic and non-linguistic domains were not tightly correlated. Poor performance in pantomime interpretation was associated with lesions in the inferior frontal, premotor and motor cortex, a portion of somatosensory cortex, and the caudate, while poor reading comprehension of actions was associated with lesions around the anterior superior temporal lobe, the anterior insula and the anterior portion of the inferior parietal lobe. Lesion size did not correlate with deficits. The lesion results for pantomime interpretation deficits demonstrate that lesions in the frontal component of the human analog of the “mirror neuron system” are associated with deficits in non-linguistic action understanding. For reading comprehension deficits, the lesion correlates are brain areas known to be involved in linguistic tasks including sentence processing and speech articulation; the parietal lesion site may also correspond to a subpart of the human mirror neuron system. These results indicate that brain areas important for the production of language and action are also recruited in their comprehension. Similar findings have been reported in electrophysiological and neuroimaging studies. Our findings now also lend neuropsychological support to an embodied view of brain organization for action processing.
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颜色与形状的关联受损，伴有失语症。
DOI：
--
发表时间：
1972
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
E. Renzi;P. Faglioni;Giuseppe Scotti;Hans Spinnler
通讯作者：
Hans Spinnler
失语症病变定位——临床-CT扫描相关性（第三部分）：失语症与无意义言语]。
DOI：
--
发表时间：
1985
期刊：
No to shinkei = Brain and nerve
影响因子：
--
作者：
K. Hojo;S. Watanabe;H. Tasaki;T. Sato;H. Metoki
通讯作者：
H. Metoki
影响因子：
2.5
作者：
N. R. Varney;A. Benton
通讯作者：
A. Benton
失语症患者的声音识别与听觉语言理解相关。
影响因子：
11
作者：
N. R. Varney
通讯作者：
N. R. Varney
DOI：
10.1037//0278-7393.16.3.430
发表时间：
1990-05
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
M. Gernsbacher;K. R. Varner;M. Faust
通讯作者：
M. Gernsbacher;K. R. Varner;M. Faust