Physiological and Biochemical Adaptations to High Altitude in Tibetan Frogs, Nanorana parkeri.
Physiological and Biochemical Adaptations to High Altitude in Tibetan Frogs, Nanorana parkeri.
复制标题
Nanorana Parkeri中藏族青蛙中高海拔地区的生理和生化适应。
DOI：
10.3389/fphys.2022.942037
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发表时间：
2022
影响因子：
4
通讯作者：
Chen, Qiang
中科院分区：
文献类型：
--
作者：
Niu, Yonggang;Zhang, Xuejing;Xu, Tisen;Li, Xiangyong;Zhang, Haiying;Wu, Anran;Storey, Kenneth B.;Chen, Qiang
西藏高原蛙(N.parkeri)为青藏高原特有种，分布于海拔2850米至5100米之间。本研究探索了该物种对高海拔的生理和生化适应，特别强调了从高海拔(4,600平方英里/秒)和低海拔(3,400平方英里/秒)收集的成虫和幼虫的血液学、氧化应激和抗氧化防御参数。血液学结果显示，在高海拔地区，白纹伊蚊的血红蛋白浓度([Hb])、红细胞压积(Hct)和红细胞(RBC)计数显著升高。高海拔青少年的红细胞大小比低海拔青少年小。高水平的GSH和GSSG仅在高海拔地区的青少年中表现出来，而在成人中则没有。高海拔地区的人也表现出较低的氧化损伤，评估为肝脏中的丙二醛(MDA)和羰基(CG)。与高原成人相比，高原成人肝脏的超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽-S转移酶的活性以及总抗氧化能力也较高。此外，在高原成人的心脏和脑中观察到较高的GPx活性和T-AOC。高原青少年肝脏CAT、GPX和T-AOC显著升高。与低海拔个体相比，高海拔青蛙心脏中的维生素C含量也更高。总而言之，与低海拔种群相比，高海拔种群显示出更健壮的血液学参数、更少的氧化损伤和更强的抗氧化防御能力，所有这些都有助于增强对高海拔环境中生存的保护。
The Xizang plateau frog, N. parkeri (Anura: Dicroglossidae), is endemic to the Tibetan Plateau, ranging from 2,850 to 5,100 m above sea level. The present study explores physiological and biochemical adaptations to high altitude in this species with a particular emphasis on parameters of hematology, oxidative stress, and antioxidant defense in adult and juvenile N. parkeri collected from high (4,600 m a.s.l) and low (3,400 m a.s.l) altitudes. Hematological results showed that hemoglobin concentration ([Hb]), hematocrit (Hct), and red blood cell (RBC) counts were significantly higher in high-altitude N. parkeri. High-altitude juveniles had lower RBC sizes than low-altitude juveniles. Higher levels of GSH and GSSG were indicated only in juveniles from high altitude, not in adults. High-altitude individuals also showed lower oxidative damage, assessed as malondialdehyde (MDA) and carbonyl groups (CG) in the liver. High-altitude adults also showed higher activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione-S-transferase (GST) as well as total antioxidant capacity (T-AOC) in the liver as compared to low-altitude adults. Moreover, higher GPX activity and T-AOC were observed in the heart and brain of high-altitude adults. Liver CAT, GPX, and T-AOC showed significant increases in high-altitude juveniles. Vitamin C content was also higher in the heart of high-altitude frogs compared to low-altitude individuals. In summary, the high-altitude population of N. parkeri showed more robust hematological parameters, less oxidative damage, and stronger antioxidant defenses than the low-altitude population, all contributing to increased protection for survival in high-altitude environments.
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DOI：
10.1016/j.cbpb.2009.08.002
发表时间：
2009-12-01
影响因子：
2.2
作者：
De Zoysa, Mahanama;Whang, Ilson;Lee, Jehee
通讯作者：
Lee, Jehee
DOI：
10.1139/z71-086
发表时间：
1971-01-01
期刊：
CANADIAN JOURNAL OF ZOOLOGY - BACK YEAR PROJECT
影响因子：
--
作者：
FRIEDMANN, GB
通讯作者：
FRIEDMANN, GB
影响因子：
2.3
作者：
Dosek, Agoston;Ohno, Hideko;Radak, Zsolt
通讯作者：
Radak, Zsolt
影响因子：
4.4
作者：
D'Alessandro A;Nemkov T;Sun K;Liu H;Song A;Monte AA;Subudhi AW;Lovering AT;Dvorkin D;Julian CG;Kevil CG;Kolluru GK;Shiva S;Gladwin MT;Xia Y;Hansen KC;Roach RC
通讯作者：
Roach RC
影响因子：
5.3
作者：
Carreau A;El Hafny-Rahbi B;Matejuk A;Grillon C;Kieda C
通讯作者：
Kieda C