Decreased cognition in children with risk factors for Alzheimer's disease.
Decreased cognition in children with risk factors for Alzheimer's disease.
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DOI：
10.1016/j.biopsych.2008.07.004
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发表时间：
2008-11-15
影响因子：
10.6
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Bloss, Cinnamon S.;Delis, Dean C.;Salmon, David P.;Bondi, Mark W.
载脂蛋白E基因的ε4等位基因（APOE-ε4）和阿尔茨海默病（AD）家族史（+FH）都是AD发生的危险因素。虽然确定AD临床前阶段的研究已证明健康成人的大脑和认知功能存在APOE-ε4和+FH相关差异，但这些因素对儿童的相对影响尚不清楚。为了调查这一问题，学龄儿童（n = 109）接受标准化成绩测试，Rey-Ostrieth复杂图形测试（复制条件; RCFT-CC），家庭病史评估和口腔拭子测试，以确定他们的APOE基因型。分析显示，相对于没有这些危险因素的儿童，同时具有APOE-ε4等位基因和AD +FH和/或显著记忆问题（MP）的儿童在几乎所有认知测试中得分较低。研究结果表明，当这两种AD风险因素都存在时，认知可能早在儿童时期就受到不利影响。因此，病理性衰老障碍的风险因素（即，AD）可能对儿童某些类型的学习困难的病因学有影响。
The ε4 allele of the apolipoprotein E gene (APOE-ε4) and a family history (+FH) of Alzheimer’s disease (AD) are both risk factors for the development of AD. While studies to identify a preclinical phase of AD have led to evidence of APOE-ε4- and +FH-related differences in brain and cognitive functioning in healthy adults, the relative influence of these factors in children is unknown. To investigate this issue, school-aged children (n = 109) received standardized achievement tests, the Rey-Osterrieth Complex Figure Test (Copy Condition; RCFT-CC), assessment of family medical history, and buccal swab testing to determine their APOE genotype. Analyses revealed that, relative to children without these risk factors, children who possess both an APOE-ε4 allele and a +FH of AD and/or significant memory problems (MP) obtained lower scores on nearly every cognitive test administered. Findings suggest that when both AD risk factors are present, cognition may be adversely impacted as early as childhood. Thus, risk factors for a disorder of pathological aging (i.e., AD) may have implications for the etiology of certain types of learning difficulties in children.
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影响因子：
3.7
作者：
Small, BJ;Rosnick, CB;B채ckman, L
通讯作者：
B채ckman, L
DOI：
10.1073/pnas.90.5.1977
发表时间：
1993-03-01
影响因子：
11.1
作者：
STRITTMATTER, WJ;SAUNDERS, AM;ROSES, AD
通讯作者：
ROSES, AD
DOI：
10.1111/j.1749-6632.2000.tb06347.x
发表时间：
2000-01-01
期刊：
VASCULAR FACTORS IN ALZHEIMER'S DISEASE
影响因子：
--
作者：
Snowdon, DA;Greiner, LH;Markesbery, WR
通讯作者：
Markesbery, WR
影响因子：
2.5
作者：
Turic, D;Fisher, PJ;Owen, MJ
通讯作者：
Owen, MJ
影响因子：
4
作者：
Becher, JC;Keeling, JW;Bell, J
通讯作者：
Bell, J