Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that Manufacture and Use BPA in the USA.
Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that Manufacture and Use BPA in the USA.
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在美国生产和使用BPA的行业工人中，尿型双酚A（BPA）浓度。
DOI：
10.1093/annweh/wxw021
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发表时间：
2017-03-01
影响因子：
2.6
通讯作者：
Calafat AM
中科院分区：
文献类型：
--
作者：
Hines CJ;Jackson MV;Deddens JA;Clark JC;Ye X;Christianson AL;Meadows JW;Calafat AM
双酚A（BPA）的毒性和对人类的暴露风险一直是相当多的科学辩论的主题;然而，发表的BPA职业暴露数据有限。在2013-2014年，六家美国公司的77名工人在连续两个工作日内（151个工作日，525个样本）提供了7份尿样。参与者的信息包括行业，工作，任务，使用的个人防护设备，卫生行为，和罐头食品/饮料消费。在所有样本中检测到总（游离加结合）BPA，通过质谱法在尿液中定量。肌酐校正的总BPA（总BPACR）浓度的几何平均值（GM）为88.0 μg g g−1（范围为0.78-18 900 μg g g−1），比2013-2014年美国成年人（1.27 μg g g−1）高约70倍。GM总BPACR在第1天增加（26.6-127 μg g−1），在第2天转换前下降（84.4 μg g−1），然后在第2天增加至178 μg g−1。按行业划分，基线和基线后总BPACR在BPA填充蜡制造/回收中最高（GM = 111 μg g-1），在酚醛树脂制造中最低（GM = 6.56 μg g-1）。按工作分类，维修工人基线时的总BPACR最高（GM = 157 μg g−1），而那些使用熔融BPA填充蜡的工人基线后的总BPACR最高（GM = 441 μg g−1）。从事双酚A树脂剥落工作的工人在基线（GM = 4.81 μg g g−1）和基线后（GM = 23.2 μg g g−1）的浓度最低。在多元回归模型中，在基线时，行业显著预测总BPACR增加（P = 0.0248）;基线后，处理BPA容器（P = 0.0035），采集≥3份含BPA的工艺/原液样品（P = 0.0002）和穿着Tyvek®工作服（P = 0.0042）显著预测总BPACR增加（在基线、时间点和体重指数校正总BPACR后）。几个工作相关的因素，包括行业，工作，并执行某些任务，与增加尿总BPACR浓度在这组制造业工人。这些工人中BPA相关健康影响的可能性尚不清楚。
Bisphenol A (BPA) toxicity and exposure risk to humans has been the subject of considerable scientific debate; however, published occupational exposure data for BPA are limited. In 2013–2014, 77 workers at six US companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine samples over two consecutive work days (151 worker-days, 525 samples). Participant information included industry, job, tasks, personal protective equipment used, hygiene behaviors, and canned food/beverage consumption. Total (free plus conjugated) BPA, quantified in urine by mass spectrometry, was detected in all samples. The geometric mean (GM) creatinine-adjusted total BPA (total BPACR) concentration was 88.0 μg g−1 (range 0.78–18 900 μg g−1), ~70 times higher than in US adults in 2013–2014 (1.27 μg g−1). GM total BPACR increased during Day 1 (26.6–127 μg g−1), decreased by pre-shift Day 2 (84.4 μg g−1) then increased during Day 2 to 178 μg g−1. By industry, baseline and post-baseline total BPACR was highest in BPA-filled wax manufacturing/reclaim (GM = 111 μg g−1) and lowest in phenolic resin manufacturing (GM = 6.56 μg g−1). By job, total BPACR was highest at baseline in maintenance workers (GM = 157 μg g−1) and post-baseline in those working with molten BPA-filled wax (GM = 441 μg g−1). Workers in the job of flaking a BPA-based resin had the lowest concentrations at baseline (GM = 4.81 μg g−1) and post-baseline (GM = 23.2 μg g−1). In multiple regression models, at baseline, industry significantly predicted increased total BPACR (P = 0.0248); post-baseline, handling BPA containers (P = 0.0035), taking ≥3 process/bulk samples with BPA (P = 0.0002) and wearing a Tyvek® coverall (P = 0.0042) significantly predicted increased total BPACR (after adjusting for total BPACR at baseline, time point, and body mass index). Several work-related factors, including industry, job, and certain tasks performed, were associated with increased urinary total BPACR concentrations in this group of manufacturing workers. The potential for BPA-related health effects among these workers is unknown.
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影响因子：
3.5
作者：
Demierre, Anne-Laure;Peter, Ronald;Bourqui-Pittet, Martine
通讯作者：
Bourqui-Pittet, Martine
影响因子：
8
作者：
Fleisch, Abby F.;Sheffield, Perry E.;Landrigan, Philip J.
通讯作者：
Landrigan, Philip J.
影响因子：
10.4
作者：
Guidry VT;Longnecker MP;Aase H;Eggesbø M;Zeiner P;Reichborn-Kjennerud T;Knudsen GP;Bertelsen RJ;Ye X;Calafat AM;Engel SM
通讯作者：
Engel SM
DOI：
10.1038/137996a0
发表时间：
1936-01-01
期刊：
NATURE [LONDON]
影响因子：
--
作者：
DODDS, E. C;LAWSON, WILFRED
通讯作者：
LAWSON, WILFRED
DOI：
10.1080/0002889748507072
发表时间：
1974-01-01
期刊：
AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL
影响因子：
--
作者：
ELKINS, HB;PAGNOTTO, LD;SMITH, HL
通讯作者：
SMITH, HL