Measurement of Total and Free Urinary Phenol and Paraben Concentrations over the Course of Pregnancy: Assessing Reliability and Contamination of Specimens in the Norwegian Mother and Child Cohort Study.
Measurement of Total and Free Urinary Phenol and Paraben Concentrations over the Course of Pregnancy: Assessing Reliability and Contamination of Specimens in the Norwegian Mother and Child Cohort Study.
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DOI：
10.1289/ehp.1408325
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发表时间：
2015-07
影响因子：
10.4
通讯作者：
Engel SM
中科院分区：
文献类型：
--
作者：
Guidry VT;Longnecker MP;Aase H;Eggesbø M;Zeiner P;Reichborn-Kjennerud T;Knudsen GP;Bertelsen RJ;Ye X;Calafat AM;Engel SM
暴露于环境酚类和对羟基苯甲酸酯可能是有害的，特别是在子宫内。先前的研究已经证明了整个妊娠期间尿液浓度的高度人内变异性。我们试图测量挪威母亲和儿童队列（MoBa）研究的苯酚和对羟基苯甲酸酯生物标志物浓度，评估人内变异性，并调查任何可能的样本外部苯酚或对羟基苯甲酸酯污染。我们在医院环境中收集了大约17周、23周和29周妊娠的三个点尿样本，并添加了含有对羟基苯甲酸乙酯的防腐剂。我们测量了MoBa样本（n = 45）中酚类和对羟基苯甲酸酯的尿液浓度和人内变异性，包括先前随机选择的双酚A（BPA）暴露研究的15名参与者的亚组，这些参与者具有异常高的总BPA浓度。此外，我们还比较了酚类化合物的总浓度、共轭浓度和游离浓度的可靠性结果。我们在100%的样品中检测到总的和游离的BPA、对羟基苯甲酸丁酯、对羟基苯甲酸丙酯和对羟基苯甲酸甲酯，在95%的样品中检测到总的二苯甲酮-3，并且很少检测到游离的二苯甲酮-3以及总的和游离的2，4-二氯苯酚和2，5-二氯苯酚。总浓度、共轭浓度和游离浓度的组内相关系数（ICC）范围从BPA的相对较低到尼泊金丙酯的中等。总体和各亚组的ICC基本相似。使用共轭浓度提高可靠性估计只有BPA。测量总浓度和游离浓度，这种方法可能对未来的研究有用，使我们能够识别存档的MoBa尿液标本中可能的BPA和对羟基苯甲酸丁酯污染。Guidry VT，Longnecker MP，Aase H，Eggesboutin M，Zeiner P，Reicham-Kjennerud T，Knudsen GP，Bertelsen RJ，Ye X，卡拉法特AM，Engel SM. 2015.妊娠过程中总的和游离的尿酚和对羟基苯甲酸酯浓度的测量：在挪威母亲和儿童队列研究中评估样本的可靠性和污染环境健康展望123：705-711; http：dx.doi.org/10.1289/ehp.1408325
Exposures to environmental phenols and parabens may be harmful, especially in utero. Prior studies have demonstrated high within-person variability of urinary concentrations across pregnancy. We sought to measure phenol and paraben biomarker concentrations for the Norwegian Mother and Child Cohort (MoBa) study, assess within-person variability, and investigate any possible external phenol or paraben contamination of specimens. We collected three spot urine samples at approximately 17, 23, and 29 weeks gestation in a hospital setting and added a preservative containing ethyl paraben. We measured urinary concentrations and within-person variability for phenols and parabens in a MoBa sample (n = 45), including a subgroup of 15 participants previously randomly selected for a bisphenol A (BPA) exposure study who had unusually high total BPA concentrations. Additionally, we compared reliability results for total, conjugated, and free concentrations of phenolic compounds. We detected total and free BPA, butyl paraben, propyl paraben, and methyl paraben in 100% of samples, total benzophenone-3 in 95% of samples, and infrequently detected free benzophenone-3 and total and free 2,4-dichlorophenol and 2,5-dichlorophenol. Intraclass correlation coefficients (ICCs) for total, conjugated, and free concentrations ranged from relatively low for BPA to moderate for propyl paraben. ICCs were generally similar overall and by subgroup. Using conjugated concentrations improved reliability estimates only for BPA. Measuring total and free concentrations, an approach that may be useful for future studies, allowed us to identify likely BPA and butyl paraben contamination of archived MoBa urine specimens. Guidry VT, Longnecker MP, Aase H, Eggesbø M, Zeiner P, Reichborn-Kjennerud T, Knudsen GP, Bertelsen RJ, Ye X, Calafat AM, Engel SM. 2015. Measurement of total and free urinary phenol and paraben concentrations over the course of pregnancy: assessing reliability and contamination of specimens in the Norwegian Mother and Child Cohort Study. Environ Health Perspect 123:705–711; http://dx.doi.org/10.1289/ehp.1408325
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
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影响因子：
10.4
作者：
Mahalingaiah, Shruthi;Meeker, John D.;Pearson, Kimberly R.;Calafat, Antonia M.;Ye, Xiaoyun;Petrozza, John;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
11.4
作者：
Liao, Chunyang;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
影响因子：
4.5
作者：
通讯作者：
--
DOI：
10.1038/jes.2012.39
发表时间：
2012-11-01
影响因子：
4.5
作者：
Koch, Holger M.;Kolossa-Gehring, Marike;Bruening, Thomas
通讯作者：
Bruening, Thomas